N-(四丁氧基羧基)-1,2,3,4-四羟基异喹啉合成路线 （共 17 条）
反应条件
sodium hydroxide in tert-butyl alcohol T=20°C; 12 h;
参考文献
Wright, Dennis L.; McMills, Mark C.
Organic Letters, 1999 , vol. 1, # 4 p. 667 - 670
参考文献
McMills, Mark C.; Wright, Dennis L.; Zubkowski, Jeffrey D.; Valente, Edward J.
Tetrahedron Letters, 1996 , vol. 37, # 40 p. 7205 - 7208
反应条件
pyridine; hydrogen; acetic acid; nickel in water T=50°C; P=2585.74 Torr;
参考文献
Van Rompaey, Karolien; Van Den Eynde, Isabelle; De Kimpe, Norbert; Tourwe, Dirk
Tetrahedron, 2003 , vol. 59, # 24 p. 4421 - 4432
反应条件
pyridine; hydrogen; acetic acid; nickel in water T=50°C; P=2585.74 Torr;
参考文献
Tetrahedron, , vol. 59, # 24 p. 4421 - 4432
反应条件
sodium hydroxide in water; tert-butyl alcohol
反应条件
triethylamine; citric acid in tetrahydrofuran; water
反应条件
triethylamine in water; acetone
参考文献
Ho, Bin; Michael Crider; Stables, James P
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 3 p. 265 - 286
反应条件
1: 84 percent / NaOH / dioxane; ethyl acetate / 20 °C / pH 8 2: 88 percent / DCC; pyridine / acetonitrile / 4 h / 20 °C 3: 97 percent / DMAP / acetonitrile / 20 °C 4: 68 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C 5: pyridine; acetic acid; H2 / Raney Ni / H2O / 50 °C / 2585.74 Torr View Scheme
参考文献
Tetrahedron, , vol. 59, # 24 p. 4421 - 4432
反应条件
1: Bu4N(HSO4); NaOH / CH2Cl2; H2O / 24 h / 20 °C 2: 85 percent / HCl / acetone; H2O / 3 h / 20 °C 3: 84 percent / HCl / acetone; H2O / 21 h / Heating 4: 84 percent / NaOH / dioxane; ethyl acetate / 20 °C / pH 8 5: 88 percent / DCC; pyridine / acetonitrile / 4 h / 20 °C 6: 97 percent / DMAP / acetonitrile / 20 °C 7: 68 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C 8: pyridine; acetic acid; H2 / Raney Ni / H2O / 50 °C / 2585.74 Torr View Scheme
参考文献
Tetrahedron, , vol. 59, # 24 p. 4421 - 4432
反应条件
1: 97 percent / DMAP / acetonitrile / 20 °C 2: 68 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C 3: pyridine; acetic acid; H2 / Raney Ni / H2O / 50 °C / 2585.74 Torr View Scheme
参考文献
Tetrahedron, , vol. 59, # 24 p. 4421 - 4432
