N-(四丁氧基羧基)-1,2,3,4-四羟基异喹啉合成路线 （共 17 条）
反应条件
1: 68 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C 2: pyridine; acetic acid; H2 / Raney Ni / H2O / 50 °C / 2585.74 Torr View Scheme
参考文献
Tetrahedron, , vol. 59, # 24 p. 4421 - 4432
参考文献
US5142056 A1, ;
US 5142056 A
反应条件
1: 83 percent / aq. HCl / 5 h / Heating 2: 70 percent / Et3N / H2O; acetone View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 36, # 3 p. 265 - 286
反应条件
1: 43 percent / NaOMe / 4 h / Heating 2: 89 percent / KOH / aq. methanol / 5 h / Heating 3: 83 percent / aq. HCl / 5 h / Heating 4: 70 percent / Et3N / H2O; acetone View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 36, # 3 p. 265 - 286
反应条件
1: 89 percent / KOH / aq. methanol / 5 h / Heating 2: 83 percent / aq. HCl / 5 h / Heating 3: 70 percent / Et3N / H2O; acetone View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 36, # 3 p. 265 - 286
反应条件
borane in tetrahydrofuran
参考文献
McMills, Mark C.; Wright, Dennis L.; Zubkowski, Jeffrey D.; Valente, Edward J.
Tetrahedron Letters, 1996 , vol. 37, # 40 p. 7205 - 7208
反应条件
borane-THF in tetrahydrofuran T=0 - 20°C;
参考文献
Wright, Dennis L.; McMills, Mark C.
Organic Letters, 1999 , vol. 1, # 4 p. 667 - 670
