3-苄基-3-氮杂双环[3.1.0]-6-己胺合成路线 （共 7 条）
反应条件
nickel; hydrazine hydrate in methanol T=5 - 20°C; 4.5 h;
参考文献
Madhusudhan; Balraju; Rajesh; Narayana, B. Venkata; Reddy
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009 , vol. 48, # 4 p. 569 - 573
反应条件
1: 43 percent / tetrabutylammonium 2,6-di-tert-butylphenoxide; 4 Angstroem molecular sieves / toluene / 1 h / -19 °C 2: 97 percent / NaBH4; BF3*THF / tetrahydrofuran / 3 h / 40 °C 3: H2; H2O / 5percent Pt/C / methanol / 24 h / 50 °C / 2660.18 Torr View Scheme
参考文献
Vempati, Ravi Kumar; Reddy; Alapati, Srinivasa Rao; Dubey
Asian Journal of Chemistry, 2013 , vol. 25, # 2 p. 986 - 994
反应条件
1: 97 percent / NaBH4; BF3*THF / tetrahydrofuran / 3 h / 40 °C 2: H2; H2O / 5percent Pt/C / methanol / 24 h / 50 °C / 2660.18 Torr View Scheme
参考文献
Vempati, Ravi Kumar; Reddy; Alapati, Srinivasa Rao; Dubey
Asian Journal of Chemistry, 2013 , vol. 25, # 2 p. 986 - 994
反应条件
water in ethanol T=100°C;
参考文献
Sattigeri, Jitendra A.; Andappan, Murugaiah M.S.; Kishore, Kaushal; Thangathirupathy, Srinivasan; Sundaram, Sinduja; Singh, Shuchita; Sharma, Suchitra; Davis, Joseph A.; Chugh, Anita; Bansal, Vinay S.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 4087 - 4091
反应条件
triethylamine in tetrahydrofuran T=10 - 20°C; 4.16667 h;
参考文献
Madhusudhan; Balraju; Rajesh; Narayana, B. Venkata; Reddy
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009 , vol. 48, # 4 p. 569 - 573
反应条件
hydrogen; triethylamine; palladium on activated charcoal in methanol P=3102.97 - 3620.13 Torr;
参考文献
GLENMARK PHARMACEUTICALS, S.A.
Patent: WO2009/90548 A2, 2009 ;
Location in patent: Page/Page column 58-59 ;
WO 2009/090548 A2
反应条件
1: Na2CO3; aq. NaOH / ethyl acetate / 3 h / 30 °C 2: 89 percent / H2O; H2 / 10percent Pd/C / methanol / 20 °C View Scheme
参考文献
Vempati, Ravi Kumar; Reddy; Alapati, Srinivasa Rao; Dubey
Asian Journal of Chemistry, 2013 , vol. 25, # 2 p. 986 - 994
