(R)-(+)-甲基对甲苯亚砜合成路线 （共 72 条）
反应条件
1: quinidine acetate / CH2Cl2 / 1 h / -78 °C 2: 93 percent / MeMgBr / toluene / 3 h / -40 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 127, # 5 p. 1374 - 1375
反应条件
(1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinyl-1-azoniabicyclo[2.2.2]octane chloride; sodium hydroxide in water; toluene T=-20°C; 36 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Organic Letters, , vol. 13, # 12 p. 3170 - 3173
反应条件
(1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinyl-1-azoniabicyclo[2.2.2]octane chloride; sodium hydroxide in water; toluene T=-20°C; 36 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Organic Letters, , vol. 13, # 12 p. 3170 - 3173
反应条件
(1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinyl-1-azoniabicyclo[2.2.2]octane chloride; sodium hydroxide in dichloromethane; toluene T=0°C; 5 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Organic Letters, , vol. 13, # 12 p. 3170 - 3173
反应条件
(1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinyl-1-azoniabicyclo[2.2.2]octane chloride; sodium hydroxide in water; toluene T=-20°C; 18 h; Inert atmosphere; optical yield given as percent ee;
参考文献
Organic Letters, , vol. 13, # 12 p. 3170 - 3173
反应条件
1: potassium carbonate / water / 20 h / 40 °C / Inert atmosphere 2: dihydrogen peroxide / 2,2,2-trifluoroethanol; water / 0 - 20 °C 3: (1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinyl-1-azoniabicyclo[2.2.2]octane chloride; sodium hydroxide / water; toluene / 36 h / -20 °C / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 12 p. 3170 - 3173
反应条件
(1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinyl-1-azoniabicyclo[2.2.2]octane chloride; sodium hydroxide in dichloromethane; water; toluene T=0°C; Inert atmosphere; optical yield given as percent ee;
参考文献
Organic Letters, , vol. 13, # 12 p. 3170 - 3173
反应条件
in tetrahydrofuran T=-78°C;
参考文献
Tetrahedron Asymmetry, , vol. 6, # 7 p. 1511 - 1514
反应条件
in tetrahydrofuran T=-78°C;
参考文献
Tetrahedron Asymmetry, , vol. 6, # 7 p. 1511 - 1514
反应条件
1: (4-Methylphenyl)-magnesium bromide; (2R,4S,5R)-4-methyl-5-phenyl-3-(toluene-4-sulfonyl)oxathiazolidine-2-oxide in tetrahydrofuran T=-70 - -65°C; Inert atmosphere; 2: methyl-magnesium chloride in tetrahydrofuran T=-10 - 0°C; Inert atmosphere;
参考文献
Organic Process Research and Development, , vol. 11, # 3 p. 605 - 608
