(R)-(+)-甲基对甲苯亚砜合成路线 （共 72 条）
反应条件
titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; 1-(5-methylfuran-2-yl)hept-1-yl hydroperoxide in dichloromethane T=20°C; 18 h;
参考文献
Tetrahedron Asymmetry, , vol. 13, # 12 p. 1277 - 1283
反应条件
in tetrahydrofuran T=-78°C;
参考文献
Tetrahedron Asymmetry, , vol. 6, # 7 p. 1511 - 1514
反应条件
in tetrahydrofuran T=-78°C;
参考文献
Tetrahedron Asymmetry, , vol. 6, # 7 p. 1511 - 1514
反应条件
1: 1.)( LiHMD, 2.) CsF / 1.) THF, a) -65 deg C, 15 min, b) RT, 5 h, 2.) THF, RT, overnight 2: tetrahydrofuran; toluene / 0.25 h / -30 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 8, # 4 p. 591 - 598
反应条件
in diethyl ether; toluene 2 h; Ambient temperature;
参考文献
Rosa, V. Guerrero-de la; Ordonez, M.; LLera, J. M.; Alcudia, F.
Synthesis, 1995 , p. 761 - 762
反应条件
1: dihydrogen peroxide / 2,2,2-trifluoroethanol; water / 0 - 20 °C 2: (1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinyl-1-azoniabicyclo[2.2.2]octane chloride; sodium hydroxide / water; toluene / 36 h / -20 °C / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 12 p. 3170 - 3173
反应条件
1: dihydrogen peroxide / 2,2,2-trifluoroethanol; water / 0 - 20 °C 2: (1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinyl-1-azoniabicyclo[2.2.2]octane chloride; sodium hydroxide / dichloromethane; water; toluene / 0 °C / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 12 p. 3170 - 3173
反应条件
1: dihydrogen peroxide / 2,2,2-trifluoroethanol; water / 0 - 20 °C 2: (1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinyl-1-azoniabicyclo[2.2.2]octane chloride; sodium hydroxide / dichloromethane; toluene / 5 h / 0 °C / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 12 p. 3170 - 3173
反应条件
1: dihydrogen peroxide / 2,2,2-trifluoroethanol; water / 0 - 20 °C 2: (1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinyl-1-azoniabicyclo[2.2.2]octane chloride; sodium hydroxide / water; toluene / 36 h / -20 °C / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 12 p. 3170 - 3173
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C 2: (1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinyl-1-azoniabicyclo[2.2.2]octane chloride; sodium hydroxide / water; toluene / 18 h / -20 °C / Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 13, # 12 p. 3170 - 3173
