(R)-(+)-甲基对甲苯亚砜合成路线 （共 72 条）
反应条件
1: 87 percent / diisopropylamine, butyllithium / tetrahydrofuran; hexane / 2 h / -78 deg C to r.t. 2: 46 percent / diisopropylamine, butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C View Scheme
参考文献
Kusuda, Shinya; Ueno, Yoshio; Toru, Takeshi
Tetrahedron, 1994 , vol. 50, # 4 p. 1045 - 1062
反应条件
1,1,3,3-tetramethyldisiloxane in dichloromethane T=80°C; 0.25 h;
参考文献
De Vekki; Skvortsov
Russian Journal of General Chemistry, 2009 , vol. 79, # 4 p. 762 - 777
反应条件
hydrogenchloride in methanol; water T=25°C; Rate constant;
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 5 p. 617 - 622
反应条件
hydrogenchloride in methanol; water T=25°C; Rate constant;
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 5 p. 617 - 622
反应条件
1: 1.) LiN(Et)2 / 1.) n-hexane, THF, -40 deg C, 40 min, 2.) n-hexane, THF, 1 h 2: 47 percent / K2CO3, 18-crown-6 / acetonitrile / 12 h / 35 - 40 °C 3: 88 percent / HCl / tetrahydrofuran / 6 h / Ambient temperature View Scheme
参考文献
Iwata; Maezaki; Hattori; Fujita; Moritani; Takemoto; Tanaka; Imanishi
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 2 p. 339 - 345
反应条件
1.1: LDA / tetrahydrofuran / -78 - 0 °C 1.2: 46 percent / Br2 / tetrahydrofuran / 0.08 h / -78 °C 2.1: CsF / Pd(PPh3)4 / tetrahydrofuran / Heating View Scheme
参考文献
Rodriguez, Nuria; Cuenca, Ana; Ramirez De Arellano, Carmen; Medio-Simon, Mercedes; Peine, Denissa; Asensio, Gregorio
Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 8070 - 8076
反应条件
1: (R)-(+)-methyl-p-tolylsulfoxide With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-30°C; 0.333333 h;
2: 1-acryloyl imidazole in tetrahydrofuran; hexane
T=-15°C; 0.333333 h;
参考文献
Raghavan, Sadagopan; Joseph
Tetrahedron Asymmetry, 2003 , vol. 14, # 1 p. 101 - 105
反应条件
lithium diisopropyl amide in tetrahydrofuran
T=-78°C;
参考文献
Geant, Pierre-Yves; Martinez, Jean; Salom-Roig, Xavier J.
European Journal of Organic Chemistry, 2012 , # 1 p. 62 - 65
反应条件
1: (R)-(+)-methyl-p-tolylsulfoxide With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78°C;
2: ethyl (2E)-3-methoxy-2-butenoate in tetrahydrofuran; hexane
T=20°C;
参考文献
Hanquet, Gilles; Salom-Roig, Xavier J.; Gressot-Kempf, Laurence; Lanners, Steve; Solladie, Guy
Tetrahedron Asymmetry, 2003 , vol. 14, # 10 p. 1291 - 1301
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran; hexane
Alkylation;
2: With hydrogenchloride in tetrahydrofuran; hexane
Hydrolysis;
参考文献
Vleggaar, Robert; Zeevaart, Jacob G.
Tetrahedron Letters, 1999 , vol. 40, # 52 p. 9301 - 9303
