a-(4-吗啉基)苯乙腈合成路线 （共 26 条）
反应条件
NiO2 in tetrahydrofuran T=20°C; 16 h;
参考文献
Yin, Zhiwei; Zhang, Zhongxing; Zhu, Juliang; Wong, Henry; Kadow, John F.; Meanwell, Nicholas A.; Wang, Tao
Tetrahedron Letters, 2005 , vol. 46, # 29 p. 4919 - 4923
反应条件
1: With 3-chloro-benzenecarboperoxoic acid in water; acetonitrile T=0°C; 2: With potassium hydroxide in water; acetonitrile 1.5 h;
参考文献
Yokoshima, Satoshi; Kubo, Tetsuji; Tokuyama, Hidetoshi; Fukuyama, Tohru
Chemistry Letters, 2002 , # 2 p. 122 - 123
反应条件
1: 1.) sodium hydride / 1.) DMF, 1 h, 2.) DMF, overnight 2: 6 N HCl / benzene / 18 h / Heating 3: 60 percent / n-butyllithium / tetrahydrofuran; diethyl ether / 0.25 h / -95 °C View Scheme
参考文献
Aidhen; Narasimhan
Tetrahedron Letters, 1991 , vol. 32, # 19 p. 2171 - 2172
反应条件
(i) NaH, (ii) /BRN= 2041517/, (iii) aq. AcOH; Multistep reaction;
参考文献
McEvoy,F.J.; Albright,J.D.
Journal of Organic Chemistry, 1979 , vol. 44, p. 4597 - 4603
反应条件
1: α-phenyl-4-morpholinoacetonitrile With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: methacrylic acid methyl ester in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Pawar; Waghmare; Lokhande
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 11 p. 2549 - 2551
反应条件
1: 1.) NaH / 1.) DMF, hexane, RT, 1 h, 2.) DMF, hexane, RT, 2 h
2: 84 percent / CuSO4*5H2O / methanol; H2O / 10 h
3: 80 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / benzene / 30 h / Heating
View Scheme
参考文献
Dhavale; Aidhen; Shafique
Journal of Organic Chemistry, 1989 , vol. 54, # 16 p. 3985 - 3987
