alpha-(4-甲氧基苯基)吗啉-4-乙腈合成路线 （共 9 条）
反应条件
1: morpholine; 4-methoxy-benzaldehyde With perchloric acid T=60°C; 2 h; 2: potassium cyanide With perchloric acid T=90°C; 2 h;
参考文献
Walker, Joel R; Curley Jr., Robert W
Tetrahedron, 2001 , vol. 57, # 31 p. 6695 - 6701
反应条件
1: morpholine; 4-methoxy-benzaldehyde With perchloric acid in water Inert atmosphereCoolingHeating; 2: potassium cyanide in water Inert atmosphereHeating;
参考文献
Barnett, Derek W.; Refaei, Maryanne S.; Curley Jr., Robert W.
Journal of Labelled Compounds and Radiopharmaceuticals, 2013 , vol. 56, # 1 p. 6 - 11
反应条件
1.) morpholine, 60 degC, 1 h; 2.) morpholine/water, 90 degC, 1 h; Yield given. Multistep reaction;
参考文献
Ramalingam, Kondareddiar; Nanjappan, Palaniappagownder; Kalvin, Douglas M.; Woodard, Ronald W.
Tetrahedron, 1988 , vol. 44, # 17 p. 5597 - 5604
反应条件
1: α-4-methoxyphenyl-α-(4-morpholino)acetonitrile With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: acrylic acid methyl ester in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Pawar; Waghmare; Lokhande
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 11 p. 2549 - 2551
反应条件
1: NaH / dimethylformamide / 1 h / 27 - 30 °C 2: CuSO4*5H2O / methanol; H2O / 1.5 h / 60 °C View Scheme
参考文献
Mahalingam, Sakkarapalayam M.; Aidhen, Indrapal Singh
Journal of Organic Chemistry, 2006 , vol. 71, # 1 p. 349 - 351
反应条件
1: α-4-methoxyphenyl-α-(4-morpholino)acetonitrile With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: methacrylic acid methyl ester in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Pawar; Waghmare; Lokhande
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 11 p. 2549 - 2551
反应条件
1: KOH, EtOH 2: aq. AcOH View Scheme
参考文献
McEvoy,F.J.; Albright,J.D.
Journal of Organic Chemistry, 1979 , vol. 44, p. 4597 - 4603
反应条件
borane-THF in tetrahydrofuran 40 h; Ambient temperature;
参考文献
Ogura, Katsuyuki; Shimamura, Yoshikazu; Fujita, Makoto
Journal of Organic Chemistry, 1991 , vol. 56, # 8 p. 2920 - 2922
反应条件
1.1: NaH / tetrahydrofuran / 6 h / 50 °C
1.2: 93 percent / D2O / tetrahydrofuran / 0.5 h / 0 °C
2.1: 97 percent / aq. HCl / 14 h / Heating
View Scheme
参考文献
Barnett, Derek W.; Refaei, Maryanne S.; Curley Jr., Robert W.
Journal of Labelled Compounds and Radiopharmaceuticals, 2013 , vol. 56, # 1 p. 6 - 11
