4,4,4-三氟-1-(4-甲氧基苯基)-1,3-丁烷二酮合成路线 （共 10 条）
反应条件
1: 1-(4-methoxyphenyl)ethanone With sodium hydride in N,N-dimethyl-formamide T=-5 - 0°C; 0.5 h; 2: ethyl-α,α,α-trifluoroacetate in N,N-dimethyl-formamide T=20°C; Claisen condensation;
参考文献
Singh, Sunil K.; Saibaba; Rao, K. Srinivasa; Reddy, P. Ganapati; Daga, Pankaj R.; Rajjak, S. Abdul; Misra, Parimal; Rao, Y. Koteswar
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 10 p. 977 - 990
参考文献
J.B. Chemicals and Pharmaceuticals Limited
Patent: US2001/47023 A1, 2001 ;
反应条件
1: With pyridine; iodine; copper(II) oxide 24 h; Reflux; 2: With potassium carbonate 10 h; Reflux;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 81, # 3 p. 369 - 372
反应条件
2,2'-bi-1H-imidazole; copper (II) acetate monohydrate; potassium carbonate in dimethyl sulfoxide T=45°C; 3 h;
参考文献
Zhou, Chunmei; Zeng, Runsheng; Zou, Jianping
Chinese Journal of Chemistry, 2010 , vol. 28, # 2 p. 294 - 298
反应条件
cesium fluoride in acetonitrile
6 h; Reflux;
参考文献
Okuma, Kentaro; Hirano, Koki; Tanabe, Yukiko; Itoyama, Ryoichi; Miura, Atsumi; Nagahora, Noriyoshi; Shioji, Kosei
Chemistry Letters, 2014 , vol. 43, # 4 p. 492 - 494
反应条件
hydrazine hydrate in ethanol
4 h; Reflux;
参考文献
Wang, Dun-Jia; Fan, Ling; Zheng, Chun-Yang; Fang, Zheng-Dong
Journal of Fluorine Chemistry, 2010 , vol. 131, # 5 p. 584 - 586
反应条件
sulfuric acid in ethanol
5 h; Reflux;
参考文献
Aggarwal, Ranjana; Kumar, Rajiv; Singh, Shiv P.
Journal of Fluorine Chemistry, 2009 , vol. 130, # 10 p. 886 - 893
反应条件
in ethanol
6 h; Reflux;
参考文献
Aggarwal, Ranjana; Kumar, Rajiv; Singh, Shiv P.
Journal of Fluorine Chemistry, 2009 , vol. 130, # 10 p. 886 - 893
反应条件
sulfuric acid in ethanol
参考文献
Sloop, Joseph C.; Bumgardner, Carl L.; Loehle, W. David
Journal of Fluorine Chemistry, 2002 , vol. 118, # 1-2 p. 135 - 147
反应条件
in ethanol
24 h; Heating;
参考文献
Uddin, Md. Jashim; Rao, P.N. Praveen; Knaus, Edward E.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5273 - 5280
