(R)-3-氨基-3-(4-氟苯基)-丙酸合成路线 （共 10 条）
反应条件
CAL-B (lipase B from Candida antarctica); water in isopropyl alcohol T=60°C; 13 h;
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 7-8 p. 917 - 923
反应条件
1: 71 percent / triethylamine / H2O; acetone / a) -5 deg C, 2 h, b) RT, 3 h 2: 73 percent / aq. KOH / Ambient temperature; penicillin acylase (EC 3.5.1.11), pH 7.5 View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 6, # 7 p. 1601 - 1610
反应条件
alanine racemase (accession number AE015451 range 4,245,041-4,246,270), cloned from the genome of Pseudomonas putida (KT2440); Taxus phenylalanine aminomutase enzyme in water; glycerol T=31°C; pH=8; 20 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 74, # 18 p. 6953 - 6959
反应条件
Taxus phenylalanine aminomutase enzyme in water; glycerol T=31°C; pH=8; 20 h; aq. phosphate bufferEnzymatic reaction; enantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 74, # 18 p. 6953 - 6959
反应条件
1: ammonium formate / ethanol / 6 h / Reflux 2: Polaromonas sp. JS666 recombinant ω-transaminase; Pyruvate / 3 h / 37 °C / pH 8.5 / aq. buffer; Resolution of racemate; Enzymatic reaction View Scheme
参考文献
Chemical Communications, , vol. 47, # 20 p. 5894 - 5896
反应条件
potassium hydroxide Ambient temperaturepenicillin acylase (EC 3.5.1.11), pH 7.5;
参考文献
Soloshonok; Fokina; Rybakova; Shishkina; Galushko; Sorochinsky; Kukhar; Savchenko; Svedas
Tetrahedron Asymmetry, 1995 , vol. 6, # 7 p. 1601 - 1610
反应条件
1.1: toluene / 8 h / 20 °C 1.2: 55 percent / Na2SO3; Na2CO3 / toluene; H2O 2.1: 48 percent / CAL-B (lipase B from Candida antarctica); water / propan-2-ol / 13 h / 60 °C View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 7-8 p. 917 - 923
反应条件
phenylalanine aminomutase T=31°C; 2 h; Enzyme kinetics;
参考文献
Journal of the American Chemical Society, , vol. 129, # 22 p. 6988 - 6989
反应条件
Lipase Amano PS in phosphate buffer Hydrolysis; resolution of racemate; pH=8.2; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 41, # 15 p. 2679 - 2681
反应条件
ammonia T=25°C; pH=9; aq. bufferEnzymatic reaction; Kinetics; regioselective reaction;
参考文献
Wu, Bian; Szymanski, Wiktor; Wybenga, Gjalt G.; Heberling, Matthew M.; Bartsch, Sebastian; Dewildeman, Stefaan; Poelarends, Gerrit J.; Feringa, Ben L.; Dijkstra, Bauke W.; Janssen, Dick B.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 2 p. 482 - 486
