4-溴-2-氟苯基苄酰氯合成路线 （共 14 条）
反应条件
pyridine in dichloromethane
T=0 - 50°C;
参考文献
Kelly, Michael G.; Kincaid, John; Duncton, Matthew; Sahasrabudhe, Kiran; Janagani, Satyanarayana; Upasani, Ravindra B.; Wu, Guoxian; Fang, Yunfeng; Wei, Zhi-Liang
Patent: US2006/194801 A1, 2006 ;
Location in patent: Page/Page column 43 ;
反应条件
AlCl3, aluminium chloride
T=120°C; 16 h;
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB
Patent: WO2006/136830 A1, 2006 ;
Location in patent: Page/Page column 212-213 ;
WO 2006/136830 A1
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
1.5 h;
参考文献
NOVARTIS AG
Patent: WO2008/148867 A2, 2008 ;
Location in patent: Page/Page column 31-32 ;
WO 2008/148867 A2
反应条件
AlCl3, aluminium chloride in 1,2-dichloro-ethane
T=20°C; 7 h; Inert atmosphere;
参考文献
Aebi, Johannes; Binggeli, Alfred; Hertel, Cornelia; Konkar, Anish Ashok; Kuehne, Holger; Kuhn, Bernd; Maerki, Hans P.; Wang, Haiyan
Patent: US2013/18055 A1, 2013 ;
Location in patent: Paragraph 0322-0323 ;
