3-(1-三苯甲游基-1H-咪唑-4-基)丙烷-1-醇合成路线 （共 18 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether 2 h; Heating;
参考文献
Stark; Purand; Huels; Ligneau; Garbarg; Schwartz; Schunack
Journal of medicinal chemistry, 1996 , vol. 39, # 6 p. 1220 - 1226
反应条件
triethylamine in N,N-dimethyl-formamide T=20°C; 2 h; Inert atmosphere;
参考文献
Wijtmans, Maikel; De Graaf, Chris; De Kloe, Gerdien; Istyastono, Enade P.; Smit, Judith; Lim, Herman; Boonnak, Ratchanok; Nijmeijer, Saskia; Smits, Rogier A.; Jongejan, Aldo; Zuiderveld, Obbe; De Esch, Iwan J. P.; Leurs, Rob
Journal of Medicinal Chemistry, 2011 , vol. 54, # 6 p. 1693 - 1703
反应条件
1: H2 / 10percent Pd/C / H2O / 4 h / 40 °C 2: sulfuric acid / 12 h / Heating 3: LiAlH4 / tetrahydrofuran / 15 h / 20 °C 4: triethylamine / dimethylformamide / 2 h / 20 °C View Scheme
参考文献
Kitbunnadaj, Ruengwit; Hoffmann, Marcel; Fratantoni, Silvina A.; Bongers, Gerold; Bakker, Remko A.; Wieland, Kerstin; El Jilali, Ahmed; De Esch, Iwan J. P.; Menge, Wiro M. P. B.; Timmerman, Henk; Leurs, Rob
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 23 p. 6309 - 6323
反应条件
1: Et3N / CH2Cl2 2: LAH / tetrahydrofuran View Scheme
参考文献
Stark; Purand; Huels; Ligneau; Garbarg; Schwartz; Schunack
Journal of medicinal chemistry, 1996 , vol. 39, # 6 p. 1220 - 1226
反应条件
1: Et3N / CH2Cl2 2: LAH / tetrahydrofuran View Scheme
参考文献
Ankersen, Michael; Crider, Michael; Liu, Shengquan; Ho, Bin; Andersen, Henrik S.; Stidsen, Carsten
Journal of the American Chemical Society, 1998 , vol. 120, # 7 p. 1368 - 1373
反应条件
in N-methyl-acetamide
参考文献
Institut National de la Sante et de la Recherche Medicale; Societe Civile Bioprojet
Patent: US5559113 A1, 1996 ;
反应条件
1: 75 percent / triethylamine / tetrahydrofuran / 16 h / 20 °C 2: 99 percent / H2 / Pd/C / methanol / 4 h 3: 70 percent / LiAlH4 / tetrahydrofuran / 6 h / Heating View Scheme
参考文献
Kitbunnadaj, Ruengwit; Hoffmann, Marcel; Fratantoni, Silvina A.; Bongers, Gerold; Bakker, Remko A.; Wieland, Kerstin; El Jilali, Ahmed; De Esch, Iwan J. P.; Menge, Wiro M. P. B.; Timmerman, Henk; Leurs, Rob
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 23 p. 6309 - 6323
反应条件
1: 99 percent / H2 / Pd/C / methanol / 4 h 2: 70 percent / LiAlH4 / tetrahydrofuran / 6 h / Heating View Scheme
参考文献
Kitbunnadaj, Ruengwit; Hoffmann, Marcel; Fratantoni, Silvina A.; Bongers, Gerold; Bakker, Remko A.; Wieland, Kerstin; El Jilali, Ahmed; De Esch, Iwan J. P.; Menge, Wiro M. P. B.; Timmerman, Henk; Leurs, Rob
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 23 p. 6309 - 6323
反应条件
1: sulfuric acid / 12 h / Heating 2: LiAlH4 / tetrahydrofuran / 15 h / 20 °C 3: triethylamine / dimethylformamide / 2 h / 20 °C View Scheme
参考文献
Wijtmans, Maikel; De Graaf, Chris; De Kloe, Gerdien; Istyastono, Enade P.; Smit, Judith; Lim, Herman; Boonnak, Ratchanok; Nijmeijer, Saskia; Smits, Rogier A.; Jongejan, Aldo; Zuiderveld, Obbe; De Esch, Iwan J. P.; Leurs, Rob
Journal of Medicinal Chemistry, 2011 , vol. 54, # 6 p. 1693 - 1703
反应条件
1: LiAlH4 / tetrahydrofuran / 15 h / 20 °C 2: triethylamine / dimethylformamide / 2 h / 20 °C View Scheme
参考文献
Wijtmans, Maikel; De Graaf, Chris; De Kloe, Gerdien; Istyastono, Enade P.; Smit, Judith; Lim, Herman; Boonnak, Ratchanok; Nijmeijer, Saskia; Smits, Rogier A.; Jongejan, Aldo; Zuiderveld, Obbe; De Esch, Iwan J. P.; Leurs, Rob
Journal of Medicinal Chemistry, 2011 , vol. 54, # 6 p. 1693 - 1703
