4-[4-(4-氟苯基)-2-(4-硝基苯基)-1H-咪唑-5-基]-吡啶合成路线 （共 6 条）
反应条件
1: 97 percent / imidazole / dimethylformamide / 18 h / Ambient temperature 2: 1.) LDA / 1.) THF, hexane, -20 deg C, 45 min, 2.) THF, hexane, from -20 deg C to RT, 2.5 h 3: NH4OAc, Cu(OAc)2*H2O, CH3CO2H / 0.67 h / 98 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 5, # 1 p. 49 - 64
反应条件
1: 100 percent / Et3N / CH2Cl2 / 0.5 h 2: 1.) LDA / 1.) THF, hexane, -20 deg C, 45 min, 2.) THF, hexane, from -20 deg C to RT, 2.5 h 3: NH4OAc, Cu(OAc)2*H2O, CH3CO2H / 0.67 h / 98 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 5, # 1 p. 49 - 64
反应条件
copper diacetate; ammonium acetate; acetic acid T=98°C; 0.666667 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 5, # 1 p. 49 - 64
反应条件
1: 1.) LDA / 1.) THF, hexane, -20 deg C, 45 min, 2.) THF, hexane, from -20 deg C to RT, 2.5 h 2: NH4OAc, Cu(OAc)2*H2O, CH3CO2H / 0.67 h / 98 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 5, # 1 p. 49 - 64
反应条件
1: 1.) LDA / 1.) THF, hexane, -20 deg C, 45 min, 2.) THF, hexane, from -20 deg C to RT, 2.5 h 2: NH4OAc, Cu(OAc)2*H2O, CH3CO2H / 0.67 h / 98 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 5, # 1 p. 49 - 64
