3,N-二甲氧基-N-甲氧基苯甲酰胺合成路线 （共 10 条）
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane T=20°C; 18 h;
参考文献
Ochiai, Koji; Takita, Satoshi; Kojima, Akihiko; Eiraku, Tomohiko; Iwase, Kazuhiko; Kishi, Tetsuya; Ohinata, Akira; Yageta, Yuichi; Yasue, Tokutaro; Adams, David R.; Kohno, Yasushi
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 375 - 381
反应条件
pyridine in tetrahydrofuran; dichloromethane T=5 - 20°C; 15 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/62145 A2, 2007 ;
Location in patent: Page/Page column 40-41 ;
WO 2007/062145 A2
反应条件
O,N-dimethyl-hydroxylamine hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane T=20°C; 18 h;
参考文献
Chan, Louis K. M.; Poole, Darren L.; Shen, Di; Healy, Mark P.; Donohoe, Timothy J.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 3 p. 761 - 765
Angew. Chem., 2014 , vol. 126, # 3 p. 908
反应条件
bis-triphenylphosphine-palladium(II) chloride; tripotassium phosphate monohydrate in ethanol T=65°C; 1.5 h; Inert atmosphere;
参考文献
Krishnamoorthy, Ravi; Lam, Sang Q.; Manley, Christopher M.; Herr, R. Jason
Journal of Organic Chemistry, 2010 , vol. 75, # 4 p. 1251 - 1258
参考文献
Bioorganic and Medicinal Chemistry, , vol. 5, # 1 p. 49 - 64
反应条件
1: in tetrahydrofuran T=0 - 20°C; 3.5 h; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water Inert atmosphere;
参考文献
Ochiai, Koji; Takita, Satoshi; Kojima, Akihiko; Eiraku, Tomohiko; Iwase, Kazuhiko; Kishi, Tetsuya; Ohinata, Akira; Yageta, Yuichi; Yasue, Tokutaro; Adams, David R.; Kohno, Yasushi
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 375 - 381
反应条件
n-butyllithium in tetrahydrofuran; hexane Inert atmosphere;
参考文献
Hayashi, Yoshio; Yamazaki, Yuri; Sumikura, Makiko; Masuda, Yurika; Hayashi, Yoshiki; Yasui, Hiroyuki; Kiso, Yoshiaki; Chinen, Takumi; Usui, Takeo; Yakushiji, Fumika; Potts, Barbara; Neuteboom, Saskia; Palladino, Michael; Lloyd, George Kenneth
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 14 p. 4279 - 4289
反应条件
in tetrahydrofuran; diethyl ether 6 h; Heating;
参考文献
Bourne, Caryl; Roy, Sucharita; Wiley, Jenny L.; Martin, Billy R.; Thomas, Brian F.; Mahadevan, Anu; Razdan, Raj K.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 24 p. 7850 - 7864
反应条件
1: tetrahydrofuran / 4 h / 0 - 20 °C
2: [(η5-C5Me5)2Rh2(μ-Cl)2Cl2]; oxygen; caesium carbonate / methanol / 12 h / 65 °C / |Sealed tube
View Scheme
参考文献
Chan, Louis K. M.; Poole, Darren L.; Shen, Di; Healy, Mark P.; Donohoe, Timothy J.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 3 p. 761 - 765
Angew. Chem., 2014 , vol. 126, # 3 p. 908
