1,1,3-三苯基-2-丙炔醇合成路线 （共 48 条）
反应条件
1: phenylacetylene With tetrabutyl-ammonium chloride; potassium hydroxide in tetrahydrofuran T=20°C; 12 h; Inert atmosphereMolecular sieve; 2: benzophenone in tetrahydrofuran T=20°C; 72 h; Inert atmosphereMolecular sieve; 3: With water; ammonium chloride in tetrahydrofuran Inert atmosphereMolecular sieve;
参考文献
Liu, Junfeng; Lin, Jin; Song, Ling
Tetrahedron Letters, 2012 , vol. 53, # 17 p. 2160 - 2163
反应条件
1: in tetrahydrofuran T=0°C; 24 h; Inert atmosphere; 2: With ammonium chloride in tetrahydrofuran Saturated solution;
参考文献
Abualhasan, Murad N.; Good, James A.D.; Wittayanarakul, Kitiyaporn; Anthony, Nahoum G.; Berretta, Giacomo; Rath, Oliver; Kozielski, Frank; Sutcliffe, Oliver B.; MacKay, Simon P.
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 483 - 498
反应条件
1: 1,1-diphenyl-2-propyn-1-ol With potassium phosphate; palladium diacetate; triethylamine; triphenylphosphine in acetonitrile Sonogashira coupling; 0.5 h; Inert atmosphere; 2: iodobenzene in acetonitrile T=20°C; Sonogashira coupling; 12 h; Inert atmosphere;
参考文献
Braga, Daniele; Jaafari, Abdelhafid; Miozzo, Luciano; Moret, Massimo; Rizzato, Silvia; Papagni, Antonio; Yassar, Abderrahim
European Journal of Organic Chemistry, 2011 , # 22 p. 4160 - 4169
反应条件
1: phenylacetylene With n-butyllithium in tetrahydrofuran; hexane T=-30°C; 0.5 h; 2: benzophenone; Lithium enolate of the acetaldehyde in tetrahydrofuran; hexane T=-70 - -40°C;
参考文献
Chemistry - A European Journal, , vol. 14, # 30 p. 9131 - 9134
反应条件
hydrogenchloride in ethanol 0.0666667 h;
参考文献
Komissarova; Aleksandrova; Stadnichuk
Russian Journal of General Chemistry, 1997 , vol. 67, # 3 p. 412 - 416
反应条件
in diethyl ether 1) room temp., 2 h; 2) reflux, 1 h;
参考文献
Adegoke, Emmanuel A.; Emokpae, T. A.; Ephraim-Bassey, H.; Oyelola, C. A.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1705 - 1708
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=-20 - 0°C; 1 h;
参考文献
Tetrahedron, , vol. 39, # 6 p. 975 - 982
参考文献
Journal of the American Chemical Society, , vol. 93, # 25 p. 6989 - 6992
反应条件
1: 30 percent / KF / dimethylformamide / 25 h / 130 °C 2: 50 percent / HCl / H2O; ethanol / Ambient temperature View Scheme
参考文献
Russian Journal of General Chemistry, , vol. 67, # 3 p. 412 - 416
反应条件
1: 30 percent / KF / dimethylformamide / 25 h / 130 °C 2: 50 percent / HCl / H2O; ethanol / Ambient temperature View Scheme
参考文献
Russian Journal of General Chemistry, , vol. 67, # 3 p. 412 - 416
