(S)-4-(4-氨基苄基)-1,3-噁唑烷-2-酮合成路线 （共 11 条）
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol P=760 Torr; Ambient temperature;
参考文献
Moloney, Gerard P.; Robertson, Alan D.; Martin, Graeme R.; MacLennan, Steven; Mathews, Neil; Dodsworth, Susan; Sang, Pang Yih; Knight, Cameron; Glen, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 15 p. 2347 - 2362
反应条件
potassium carbonate T=115 - 135°C; 2.5 h;
参考文献
NATCO PHARMA LIMITED; BHUJANGA RAO, Adibhatla, Kali, Satya; NANNAPANENI, Venkaiah, Chowdary
Patent: WO2004/63175 A1, 2004 ;
Location in patent: Page 9; 12; 14; 16-18 ;
反应条件
1: 53 percent / conc. H2SO4, conc. HNO3 / 0.5 h / Ambient temperature 2: 76 percent / SOCl2 / 4 h / -10 - 40 °C 3: 65 percent / NaBH4 / ethanol; H2O / 4 h / Heating 4: 75 percent / 0.2M aq. KOH / toluene / 2 h / 0 - 20 °C 5: 79 percent / H2, aq. HCl / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 15 p. 2347 - 2362
反应条件
1: 76 percent / SOCl2 / 4 h / -10 - 40 °C 2: 65 percent / NaBH4 / ethanol; H2O / 4 h / Heating 3: 75 percent / 0.2M aq. KOH / toluene / 2 h / 0 - 20 °C 4: 79 percent / H2, aq. HCl / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 15 p. 2347 - 2362
反应条件
1: 75 percent / 0.2M aq. KOH / toluene / 2 h / 0 - 20 °C 2: 79 percent / H2, aq. HCl / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 15 p. 2347 - 2362
反应条件
1: 65 percent / NaBH4 / ethanol; H2O / 4 h / Heating 2: 75 percent / 0.2M aq. KOH / toluene / 2 h / 0 - 20 °C 3: 79 percent / H2, aq. HCl / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 15 p. 2347 - 2362
反应条件
sodium methylate in methanol; butan-1-ol T=5 - 85°C; 8.5 h;
参考文献
EP1227095 A2, ;
Example 1 ;
反应条件
1: 65 percent / fuming HNO3 / CH2Cl2 / 2 h / 20 °C 2: 47 percent / NH4Cl; In / ethanol / 4 h / Heating View Scheme
参考文献
Bioorganic Chemistry, , vol. 30, # 5 p. 315 - 331
反应条件
1: (S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one With hydrogenchloride; sodium nitrite in water T=0°C; 0.5 h; 2: With Na2S2O5; sodium hydroxide in water T=2 - 60°C; 1.25 h; Heating / reflux; 3: 4-(N,N-dimethylamino)butyraldehyde diethyl acetal With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
NATCO PHARMA LIMITED; KOMPELLA, Amala, Kisham; RACHAKONDA, Sreenivas; ADIBHATLA KALI SATYA, Bhujanga, Rao; VENKAIAH CHOWDARY, Nannapaneni
Patent: WO2008/7390 A2, 2008 ;
Location in patent: Page/Page column 6 ;
反应条件
1.1: hydrogenchloride; sodium nitrite / water / -10 - 30 °C 2.1: hydrogenchloride; tin(ll) chloride / water / 4 h / -10 - 5 °C 2.2: pH 8 - 9 3.1: water / 25 - 30 °C / pH 9 3.2: 85 - 90 °C / pH 2 3.3: pH 8 - 9 View Scheme
参考文献
GENERICS [UK] LIMITED
Patent: US2011/112157 A1, 2011 ;
