1: 38 percent / 35 h / 0.1 M phosphate buffer (pH 7.0), Pseudomonas sp. (SAM II) lipase 2: 1.) trimethyloxonium tetrafluoroborate, 2.) aq. NaOH / 1.) CH2Cl2, RT, 2 h, 2.) CH2Cl2, 2.5 h View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103233', constants.ctx, '0')">pyridine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '110354', constants.ctx, '0')">4-(N,N-dimethlyamino)pyridine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />4&nbsp;h;&nbsp;&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, a) RT, 1 h, b) reflux, 2 h<br />2: 76 percent / pyridine, N,N-dimethyl-4-aminopyridine (DMAP) / CH₂Cl₂ / 4 h / Ambient temperature<br /> <br /> &nbsp;