3-溴-6-甲氧基-苯-1,2,4,5-D4合成路线 （共 5 条）
反应条件
1.1: Br2 / dioxane 2.1: NaOH / H2O 2.2: 3.8 g / tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Cho; Beale; Graff; Mocek; Nakagawa; Omura; Floss
Journal of the American Chemical Society, 1993 , vol. 115, # 26 p. 12296 - 12304
反应条件
potassium carbonate in acetone 12 h; Heating;
参考文献
Cho; Beale; Graff; Mocek; Nakagawa; Omura; Floss
Journal of the American Chemical Society, 1993 , vol. 115, # 26 p. 12296 - 12304
反应条件
1: C6(2)H5BrO With sodium hydroxide in water 2: methyl iodide in tetrahydrofuran T=20°C; 24 h;
参考文献
Kamo, Tsunashi; Hirai, Nobuhiro; Tsuda, Mitsuya; Fujioka, Daie; Ohigashi, Hajime
Bioscience, Biotechnology and Biochemistry, 2000 , vol. 64, # 10 p. 2089 - 2098
反应条件
magnesium 1.) THF, reflux, 30 min, 2.) THF, 10 min; Yield given. Multistep reaction;
参考文献
Cho; Beale; Graff; Mocek; Nakagawa; Omura; Floss
Journal of the American Chemical Society, 1993 , vol. 115, # 26 p. 12296 - 12304
反应条件
1: 1.) Mg / 1.) THF, reflux, 30 min, 2.) THF, 10 min 2: BBr3 / CH2Cl2 / 8 h / Ambient temperature View Scheme
参考文献
Cho; Beale; Graff; Mocek; Nakagawa; Omura; Floss
Journal of the American Chemical Society, 1993 , vol. 115, # 26 p. 12296 - 12304
