11-[2-[6-[甲基-[8-[甲基-[6-[[2-氧代-2-(6-氧代-5H-吡啶并[2,3-b][1,4]苯并二氮杂卓-11-基)乙基]氨基]己基]氨基]辛基]氨基]己基-[2-氧代-2-(6-氧代-5H-吡啶并[2,3-b][1,4]苯并二氮杂卓-11-基)乙基]氨基]乙酰基]-5H-吡啶并[2,3-b][1,4]苯并二氮杂卓-6-酮合成路线 （共 7 条）
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol T=50°C; P=3800 Torr; 12 h;
参考文献
Melchiorre, Carlo; Bolognesi, Maria L.; Chiarini, Alberto; Minarini, Anna; Spampinato, Santi
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3734 - 3737
反应条件
1: 2.) NaBH4 / 1.) benzene, reflux, 6 h, 2.) EtOH, RT, 3 h 2: 32 percent / Et3N, KI / dimethylformamide / 72 h / Ambient temperature 3: 24 percent / H2, 3 N HCl / 10percent Pd/C / ethanol / 12 h / 50 °C / 3800 Torr 4: 70 percent / Et3N, KI / dimethylformamide / 72 h / Ambient temperature 5: 67 percent / H2, 3 N HCl / 10percent Pd/C / ethanol / 12 h / 50 °C / 3800 Torr View Scheme
参考文献
Melchiorre, Carlo; Bolognesi, Maria L.; Chiarini, Alberto; Minarini, Anna; Spampinato, Santi
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3734 - 3737
反应条件
1: 70 percent / Et3N, KI / dimethylformamide / 72 h / Ambient temperature 2: 67 percent / H2, 3 N HCl / 10percent Pd/C / ethanol / 12 h / 50 °C / 3800 Torr View Scheme
参考文献
Melchiorre, Carlo; Bolognesi, Maria L.; Chiarini, Alberto; Minarini, Anna; Spampinato, Santi
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3734 - 3737
反应条件
1: 24 percent / H2, 3 N HCl / 10percent Pd/C / ethanol / 12 h / 50 °C / 3800 Torr 2: 70 percent / Et3N, KI / dimethylformamide / 72 h / Ambient temperature 3: 67 percent / H2, 3 N HCl / 10percent Pd/C / ethanol / 12 h / 50 °C / 3800 Torr View Scheme
参考文献
Melchiorre, Carlo; Bolognesi, Maria L.; Chiarini, Alberto; Minarini, Anna; Spampinato, Santi
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3734 - 3737
反应条件
1: 32 percent / Et3N, KI / dimethylformamide / 72 h / Ambient temperature 2: 24 percent / H2, 3 N HCl / 10percent Pd/C / ethanol / 12 h / 50 °C / 3800 Torr 3: 70 percent / Et3N, KI / dimethylformamide / 72 h / Ambient temperature 4: 67 percent / H2, 3 N HCl / 10percent Pd/C / ethanol / 12 h / 50 °C / 3800 Torr View Scheme
参考文献
Melchiorre, Carlo; Bolognesi, Maria L.; Chiarini, Alberto; Minarini, Anna; Spampinato, Santi
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3734 - 3737
反应条件
in N,N-dimethyl-formamide 36 h; Ambient temperature;
参考文献
Minarini, Anna; Bolognesi, Maria L.; Budriesi, Roberta; Canossa, Marco; Chiarini, Alberto; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3363 - 3372
反应条件
in N,N-dimethyl-formamide 18 h; Ambient temperature;
参考文献
Minarini, Anna; Bolognesi, Maria L.; Budriesi, Roberta; Canossa, Marco; Chiarini, Alberto; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3363 - 3372
