2,6-二氟-3-羟基苯甲醛合成路线 （共 8 条）
反应条件
in tetrahydrofuran; hexane T=-78 - 20°C; 17 h;
参考文献
WO2005/92858 A2, ;
Page/Page column 78-79 ;
WO 2005/092858 A2
反应条件
1: 90 percent / K2CO3 / acetone / Heating 2: 1.) n-BuLi / 1.) THF, hexane, -75 deg C, 30 min, 2.) THF, hexane, a) -75 deg C, 15 min, b) from -75 deg C to RT, 30 min 3: 0.14 g / Et3N, H2 / 15percent Pd/C / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 24 p. 3947 - 3955
反应条件
hydrogen; triethylamine; palladium on activated charcoal in methanol
参考文献
Chen, George T.; King, Michael; Gusovsky, Fabian; Creveling, Cyrus R.; Daly, John W.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3947 - 3955
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -75 deg C, 30 min, 2.) THF, hexane, a) -75 deg C, 15 min, b) from -75 deg C to RT, 30 min 2: 0.14 g / Et3N, H2 / 15percent Pd/C / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 24 p. 3947 - 3955
反应条件
hydrogenchloride; water in methanol 1 h; Inert atmosphere;
参考文献
Sorto, Nohemy A.; Olmstead, Marilyn M.; Shaw, Jared T.
Journal of Organic Chemistry, 2010 , vol. 75, # 22 p. 7946 - 7949
反应条件
hydrogenchloride Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 24 p. 3947 - 3955
反应条件
1: 1.) sec-BuLi / 1.) THF, hexane, -65 deg C, 2.) THF, hexane, RT, 2.5 h 2: 10percent aq. HCl View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 24 p. 3947 - 3955
反应条件
sodium tetrahydroborate in tetrahydrofuran; methanol; hexane
T=0 - 20°C; 1.5 h;
参考文献
PFIZER JAPAN INC.; HASHIZUME, Yoshinobu; PFIZER INC.
Patent: WO2005/92858 A2, 2005 ;
Location in patent: Page/Page column 78-79 ;
WO 2005/092858 A2
