反应条件
1: 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[(4-oxo-2-pyrimidinyl)amino]-phenyl]benzamide With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane T=20°C; 2 h; Inert atmosphere; 2: pyridin-3-yl boronic acid With bis-triphenylphosphine-palladium(II) chloride in 1,4-dioxane T=20°C; 0.5 h; Inert atmosphere; 3: With sodium carbonate in 1,4-dioxane; water T=100°C; 24 h; Inert atmosphere; Reagent/catalyst;
参考文献
GRINDEKS, A JOINT STOCK COMPANY; LUSIS, Viesturs; STUPNIKOVA, Svetlana; MUCENIECE, Dzintra; ZANDERSONS, Armands; LAIPNIEKS, Deniss; LAVRINOVICS, Edvards; JONANE-OSA, Indra
Patent: WO2013/120852 A1, 2013 ;
Location in patent: Page/Page column 13; 14 ;
