N-(5-氨基-2-甲基苯基)-4-(3-吡啶基)-2-氨基嘧啶合成路线 （共 15 条）
反应条件
potassium carbonate in tetrahydrofuran T=0 - 20°C; 1.16667 - 4.25 h; Conversion of starting material;
参考文献
INSTYTUT FARMACEUTYCZNY
Patent: WO2006/71130 A2, 2006 ;
Location in patent: Page/Page column 25-27 ;
反应条件
1: 4-(chloromethyl)benzoic acid With thionyl chloride in 1,4-dioxane; N,N-dimethyl-formamide T=65 - 70°C; 10 - 12 h; 2: N-(5-amino-2-methylphenyl)-4-(pyridin-3-yl)-2-pyrimidine-amine With pyridine in tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide T=-5 - 5°C; 1 - 1.5 h;
参考文献
ACTAVIS GROUP PTC EHF; KHUNT, Mayur, Devjibhai; PATIL, Nilesh, Sudhir; PAGIRE, Haushabhau, Shivaji; PRADHAN, Nitin, Sharadchandra
Patent: WO2011/95835 A1, 2011 ;
Location in patent: Page/Page column 32 ;
反应条件
pyridine T=50°C; 4.5 h;
参考文献
CHEMAGIS LTD.
Patent: EP1857454 A1, 2007 ;
Location in patent: Page/Page column 4 ;
反应条件
sodium methylate in tetrahydrofuran T=70°C;
参考文献
Shen, Xin; He, Xiao; Yang, Jidong; Wu, Shaohong; Zhan, Huaxing
Patent: US2013/41149 A1, 2013 ;
Location in patent: Paragraph 0025 ;
反应条件
sodium methylate in dichloromethane T=40°C;
参考文献
Shen, Xin; He, Xiao; Yang, Jidong; Wu, Shaohong; Zhan, Huaxing
Patent: US2013/41149 A1, 2013 ;
Location in patent: Paragraph 0028 ;
反应条件
sodium ethanolate in toluene T=50°C; Reagent/catalystSolvent;
参考文献
Shen, Xin; He, Xiao; Yang, Jidong; Wu, Shaohong; Zhan, Huaxing
Patent: US2013/41149 A1, 2013 ;
Location in patent: Paragraph 0029 ;
反应条件
potassium tert-butylate in N,N-dimethyl-formamide T=50°C; Large scale;
参考文献
Shen, Xin; He, Xiao; Yang, Jidong; Wu, Shaohong; Zhan, Huaxing
Patent: US2013/41149 A1, 2013 ;
Location in patent: Paragraph 0030 ;
反应条件
n-butyllithium in acetonitrile T=20°C;
参考文献
Shen, Xin; He, Xiao; Yang, Jidong; Wu, Shaohong; Zhan, Huaxing
Patent: US2013/41149 A1, 2013 ;
Location in patent: Paragraph 0031 ;
反应条件
CsOH in propan-1-ol T=80°C;
参考文献
Shen, Xin; He, Xiao; Yang, Jidong; Wu, Shaohong; Zhan, Huaxing
Patent: US2013/41149 A1, 2013 ;
Location in patent: Paragraph 0032 ;
反应条件
potassium carbonate in ethyl acetate T=50°C; Reagent/catalystSolvent;
参考文献
Shen, Xin; He, Xiao; Yang, Jidong; Wu, Shaohong; Zhan, Huaxing
Patent: US2013/41149 A1, 2013 ;
Location in patent: Paragraph 0033 ;
