N-(5-氨基-2-甲基苯基)-4-(3-吡啶基)-2-氨基嘧啶合成路线 （共 15 条）
反应条件
1: 4-((4-methylpiperazin-1-yl)methyl)benzoic acid With pyridine; thionyl chloride T=0 - 50°C; 1 - 2 h; 2: N-(5-amino-2-methylphenyl)-4-(pyridin-3-yl)-2-pyrimidine-amine With pyridine T=0 - 20°C; 1 h; Product distribution / selectivity;
参考文献
MacDonald, Peter; Rossetto, Pierluigi
Patent: US2008/103305 A1, 2008 ;
Location in patent: Page/Page column 6 ;
反应条件
1: 4-(4-methylpiperazinomethyl)benzoic acid dihydrochloride With 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide T=50°C; 2 h; 2: N-(5-amino-2-methylphenyl)-4-(pyridin-3-yl)-2-pyrimidine-amine in N,N-dimethyl-formamide T=70°C; 12 h;
参考文献
Liu, Haiyan; Xia, Wenpin; Luo, Yu; Lu, Wei
Monatshefte fur Chemie, 2010 , vol. 141, # 8 p. 907 - 911
反应条件
1: in acetonitrile T=20 - 25°C; 4.08333 h; 2: With sodium hydroxide; water in acetonitrile T=20 - 25°C; 2.16667 h; Product distribution / selectivity;
参考文献
SYNTHON B.V.
Patent: WO2009/80366 A1, 2009 ;
Location in patent: Page/Page column 9 ;
反应条件
1: 61 percent / dimethylformamide / 2 h / 0 °C 2: 68 percent / acetonitrile / 6 h / Heating View Scheme
参考文献
Liu, Yi-Feng; Wang, Cui-Ling; Bai, Ya-Jun; Han, Ning; Jiao, Jun-Ping; Qi, Xiao-Li
Organic Process Research and Development, 2008 , vol. 12, # 3 p. 490 - 495
反应条件
pyridine in 1-methyl-pyrrolidin-2-one T=40 - 80°C;
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 7 p. 3033 - 3047
