1: carbon disulfide; acetylacetone With potassium carbonate in N,N-dimethyl-formamide 0.5 h; 2: ethyl bromoacetate in N,N-dimethyl-formamide T=0 - 20°C;

1: ethyl 4-acetyl-3-methyl-5-methylsulfanylthiophene-2-carboxylate With sodium sulfide in N,N-dimethyl-formamide T=50°C; 1 h; 2: ethyl bromoacetate With potassium carbonate in N,N-dimethyl-formamide T=50°C; 6 h;

potassium carbonate in ethanol 6 h; Heating;

tetrabutylammomium bromide; potassium carbonate 1.) benzene, 2.) benzene, 60 deg, 6 h; Yield given. Multistep reaction;

1: aq. NaOH / ethanol / 2 h / Heating 2: quinoline; copper bronze / 1 h / Heating View Scheme