2-正丙基-4-甲基-6-(1’-甲基苯并咪唑-2-基)苯并咪唑合成路线 （共 24 条）
反应条件
1: With PPA T=70 - 135°C; 13.5 h; 2: With ammonia in water T=30 - 90°C; pH=8.0 - 8.5; 1 h;
参考文献
MATRIX LABORATORIES LIMITED
Patent: WO2007/10558 A1, 2007 ;
Location in patent: Page/Page column 5; 10-11 ;
反应条件
sodium dithionite in methanol; water 12 h; Reflux;
参考文献
Wang, Ping; Zheng, Guo-Jun; Wang, Ya-Ping; Wang, Xiang-Jing; Wei, He-Geng; Xiang, Wen-Sheng
Tetrahedron, 2012 , vol. 68, # 11 p. 2509 - 2512
反应条件
1: With methanesulfonic acid; phosphorous pentoxide T=75 - 145°C; 2: With sodium hydroxide in water pH=< 3; Product distribution / selectivity;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2011/190508 A1, 2011 ;
Location in patent: Page/Page column 2 ;
反应条件
1: With phosphorous pentoxide; phosphoric acid T=70 - 130°C; 2: With ammonia in water; ethyl acetate pH=9 - 10; 3 h; Cooling with ice; Product distribution / selectivity;
参考文献
OGENE SYSTEMS (I) PVT LTD; LAKKOJU, Chakrapani; KONETI, Naga Raju; KOKKALLA, Sridhar; MALLELA, Sambhu Prasad Sarma; BOYAPATI, Nanoranjan Choudary
Patent: WO2012/28925 A2, 2012 ;
Location in patent: Page/Page column 19 ;
反应条件
1: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 2: glacial CH3COOH / 1.5 h / Heating 3: 5.46 g / aq. NaOH / methanol / 2 h / Heating 4: 5.86 g / polyphosphoric acid / 20 h / 150 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051
反应条件
1: chlorobenzene / 100 °C 2: fuming HNO3, 60percent H2SO4 / 0 °C 3: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 4: glacial CH3COOH / 1.5 h / Heating 5: 5.46 g / aq. NaOH / methanol / 2 h / Heating 6: 5.86 g / polyphosphoric acid / 20 h / 150 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051
反应条件
1: fuming HNO3, 60percent H2SO4 / 0 °C 2: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 3: glacial CH3COOH / 1.5 h / Heating 4: 5.46 g / aq. NaOH / methanol / 2 h / Heating 5: 5.86 g / polyphosphoric acid / 20 h / 150 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051
反应条件
1: With PPA T=150 - 155°C; 2: With sodium hydroxide in water T=70 - 80°C; pH=5 - 6; 0.5 - 0.75 h; Product distribution / selectivity;
参考文献
WO2006/44754 A2, ;
Page/Page column 30 ;
反应条件
1: With PPA T=150 - 155°C; 2: With sodium hydroxide in water T=70 - 80°C; pH=5 - 6; 0.5 - 0.75 h; Product distribution / selectivity;
参考文献
WO2006/44754 A2, ;
Page/Page column 31 ;
反应条件
1: 5.46 g / aq. NaOH / methanol / 2 h / Heating 2: 5.86 g / polyphosphoric acid / 20 h / 150 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051
