2-正丙基-4-甲基-6-(1’-甲基苯并咪唑-2-基)苯并咪唑合成路线 （共 24 条）
反应条件
polyphosphoric acid T=150 - 155°C;
参考文献
Reddy, Kikkuru Srirami; Srinivasan, Neti; Reddy, Chinta Raveendra; Kolla, Naveenkumar; Anjaneyulu, Yerremilli; Venkatraman, Sundaram; Bhattacharya, Apurba; Mathad, Vijayavitthal T.
Organic Process Research and Development, 2007 , vol. 11, # 1 p. 81 - 85
反应条件
1: glacial CH3COOH / 1.5 h / Heating 2: 5.46 g / aq. NaOH / methanol / 2 h / Heating 3: 5.86 g / polyphosphoric acid / 20 h / 150 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h 1.2: 3.5 h / 5 - 20 °C 2.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 3.1: sodium dithionite / methanol; water / 12 h / Reflux View Scheme
参考文献
Tetrahedron, , vol. 68, # 11 p. 2509 - 2512
反应条件
1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 2: sodium dithionite / methanol; water / 12 h / Reflux View Scheme
参考文献
Tetrahedron, , vol. 68, # 11 p. 2509 - 2512
反应条件
1.1: nitric acid / 1.67 h / -15 °C 2.1: sodium hydroxide / water / 0.5 h 2.2: 6.25 h / 0 - 70 °C 3.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C 4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h 4.2: 3.5 h / 5 - 20 °C 5.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 6.1: sodium dithionite / methanol; water / 12 h / Reflux View Scheme
参考文献
Tetrahedron, , vol. 68, # 11 p. 2509 - 2512
反应条件
1.1: sodium hydroxide / water / 0.5 h 1.2: 6.25 h / 0 - 70 °C 2.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h 3.2: 3.5 h / 5 - 20 °C 4.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 5.1: sodium dithionite / methanol; water / 12 h / Reflux View Scheme
参考文献
Tetrahedron, , vol. 68, # 11 p. 2509 - 2512
反应条件
1.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h 2.2: 3.5 h / 5 - 20 °C 3.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 4.1: sodium dithionite / methanol; water / 12 h / Reflux View Scheme
参考文献
Tetrahedron, , vol. 68, # 11 p. 2509 - 2512
反应条件
1.1: sodium hydroxide / water / 6.5 h / 60 °C 2.1: nitric acid / 1.67 h / -15 °C 3.1: sodium hydroxide / water / 0.5 h 3.2: 6.25 h / 0 - 70 °C 4.1: dihydrogen peroxide / methanol; water / 4 h / 5 - 10 °C 5.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h 5.2: 3.5 h / 5 - 20 °C 6.1: ammonia / ethanol; water / 6 h / 90 °C / Autoclave 7.1: sodium dithionite / methanol; water / 12 h / Reflux View Scheme
参考文献
Tetrahedron, , vol. 68, # 11 p. 2509 - 2512
反应条件
1: 2-n-propyl-4-methyl-6-(1'-methylbenzimidazol-2'-yl)benzimidazole With potassium tert-butylate in dimethyl sulfoxide; isopropyl alcohol Inert atmosphere; 2: methyl 4'-(bromomethyl)biphenyl-2-carboxylate in dimethyl sulfoxide; isopropyl alcohol T=30 - 35°C; 6 h; Inert atmosphere;
参考文献
WO2011/102645 A2, ;
Page/Page column 13 ;
反应条件
potassium tert-butylate in N,N-dimethyl acetamide T=75 - 80°C; 3 h; Inert atmosphere;
参考文献
Kumar, A. Sanjeev; Ghosh, Samir; Mehta
Journal of Chemical Research, 2010 , # 2 p. 95 - 97
