2-正丙基-4-甲基-6-(1’-甲基苯并咪唑-2-基)苯并咪唑合成路线 （共 24 条）
反应条件
1: 2-n-propyl-4-methyl-6-(1'-methylbenzimidazol-2'-yl)benzimidazole With potassium tert-butylate in isobutyramide T=20°C; 1 h; 2: 2-[4-(bromomethyl)phenyl]benzonitrile in isobutyramide T=5 - 10°C; 2 h;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2004/236113 A1, 2004 ;
Location in patent: Page 4 ;
反应条件
tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide in water T=80 - 85°C; 4 h; Concentration;
参考文献
U AMARNATH, Amarnath; U SURYAKIRAN, Suryakiran
Patent: WO2014/27280 A1, 2014 ;
Location in patent: Page/Page column 6-7 ;
反应条件
1: With potassium hydroxide in dimethyl sulfoxide T=25 - 50°C; 4 h; 2: With water; acetic acid in water; dimethyl sulfoxide T=20°C; pH=3.8 - 4; Product distribution / selectivity;
参考文献
CIPLA LIMITED; TURNER, Craig, Robert
Patent: WO2005/108375 A1, 2005 ;
Location in patent: Page/Page column 2-4,7,9-10 ;
反应条件
1: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h 2: CF3COOH / CH2Cl2 / 24 h / Ambient temperature View Scheme
参考文献
Reddy, Kikkuru Srirami; Srinivasan, Neti; Reddy, Chinta Raveendra; Kolla, Naveenkumar; Anjaneyulu, Yerremilli; Venkatraman, Sundaram; Bhattacharya, Apurba; Mathad, Vijayavitthal T.
Organic Process Research and Development, 2007 , vol. 11, # 1 p. 81 - 85
