2-正丙基-4-甲基-6-羧基苯并咪唑合成路线 （共 25 条）
反应条件
sodium dithionite; water T=70 - 100°C;
参考文献
OGENE SYSTEMS (I) PVT LTD; LAKKOJU, Chakrapani; KONETI, Naga Raju; KOKKALLA, Sridhar; MALLELA, Sambhu Prasad Sarma; BOYAPATI, Nanoranjan Choudary
Patent: WO2012/28925 A2, 2012 ;
Location in patent: Page/Page column 18 ;
反应条件
water; potassium carbonate; triphenylphosphine; palladium dichloride in 1,4-dioxane T=60 - 100°C; P=6750.68 - 10501.1 Torr; 49.5 h; Autoclave; Product distribution / selectivity;
参考文献
LONZA LTD; BUeCHNER, Thomas; DRESSEL, Martina; HANSELMANN, Paul; KAISER, Rafael; KLEGRAF, Ellen; ZARAGOZA DOeRWALD, Florencio; DING, Zunliang; WONG, Heilam
Patent: WO2010/81670 A2, 2010 ;
Location in patent: Page/Page column 22 ;
反应条件
sodium hydroxide; water in methanol 2 h; Heating;
参考文献
Yang, Ling-Chun; Qi, Chuan-Min; Zhang, Guan-Xin; Zou, Nan-Zhi
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1107 - 1112
反应条件
hydrogenchloride; water in 1,4-dioxane T=100°C; 16 h;
参考文献
LONZA LTD; HANSELMANN, Paul; WONG, Heilam; KLEGRAF, Ellen; ZARAGOZA DOeRWALD, Florencio; DING, Zunliang; LONG, Jun
Patent: WO2010/149360 A1, 2010 ;
Location in patent: Page/Page column 11 ;
反应条件
sodium dithionite in ethanol; water T=70°C; 2 h;
参考文献
LONZA LTD; HANSELMANN, Paul; WONG, Heilam; KLEGRAF, Ellen; ZARAGOZA DOeRWALD, Florencio; DING, Zunliang; HE, Wei (Ryan)
Patent: WO2010/149359 A1, 2010 ;
Location in patent: Page/Page column 12 ;
反应条件
1: 90 percent / acetic acid / 2 h / Heating 2: 82.3 percent / NaOH; water / methanol / 2 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 40, # 6 p. 1107 - 1112
反应条件
1: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C 2: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C 3: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 4: 90 percent / acetic acid / 2 h / Heating 5: 82.3 percent / NaOH; water / methanol / 2 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 40, # 6 p. 1107 - 1112
反应条件
1: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C 2: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 3: 90 percent / acetic acid / 2 h / Heating 4: 82.3 percent / NaOH; water / methanol / 2 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 40, # 6 p. 1107 - 1112
反应条件
1: With sodium hydroxide in ethanol; water T=90°C; 2: With hydrogenchloride in water pH=6; Product distribution / selectivity;
参考文献
WO2010/81670 A2, ;
Page/Page column 22 - 23 ;
反应条件
1: 74.3 percent / sulfuric acid / 2 h / Heating 2: 92.1 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 3: 79.6 percent / triethylamine / CH2Cl2 / 1 h / 20 °C 4: 75.6 percent / nitric acid / 1.5 h / -20 - -15 °C 5: 92 percent / aq. hydrazine / Raney Ni / methanol / 20 °C 6: 90 percent / acetic acid / 2 h / Heating 7: 82.3 percent / NaOH; water / methanol / 2 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 40, # 6 p. 1107 - 1112
