2,6-二甲基-4-(2-甲基-1H-四唑-5-亚基)环己-2,5-二烯-1-酮合成路线 （共 4 条）
反应条件
boron tribromide in dichloromethane
参考文献
Diana, Guy D.; Cutcliffe, David; Volkots, Deborah L.; Mallamo, John P.; Bailey, Thomas R.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3240 - 3250
反应条件
1: 93.2 percent / K2CO3 / acetone / 18 h / Heating 2: 62 percent / NaN3, NH4Cl / dimethylformamide / 24 h / 110 °C 3: 67 percent / K2CO3 / acetonitrile / 1 h / Heating 4: 96 percent / BBr3 / CH2Cl2 View Scheme
参考文献
Sterling Winthrop Inc.
Patent: US5364865 A1, 1994 ;
反应条件
1: 62 percent / NaN3, NH4Cl / dimethylformamide / 24 h / 110 °C 2: 67 percent / K2CO3 / acetonitrile / 1 h / Heating 3: 96 percent / BBr3 / CH2Cl2 View Scheme
参考文献
Diana, Guy D.; Cutcliffe, David; Volkots, Deborah L.; Mallamo, John P.; Bailey, Thomas R.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3240 - 3250
反应条件
1: 67 percent / K2CO3 / acetonitrile / 1 h / Heating 2: 96 percent / BBr3 / CH2Cl2 View Scheme
参考文献
Diana, Guy D.; Cutcliffe, David; Volkots, Deborah L.; Mallamo, John P.; Bailey, Thomas R.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3240 - 3250
