5-溴-2-甲氧基-3-硝基砒啶合成路线 （共 16 条）
反应条件
silver carbonate in chloroform T=20°C; 48 h;
参考文献
CGI PHARMACEUTICALS, INC.
Patent: WO2008/33854 A1, 2008 ;
Location in patent: Page/Page column 74 ;
反应条件
in methanol T=0 - 20°C; 19.1667 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/39140 A1, 2009 ;
Location in patent: Page/Page column 52 ;
WO 2009/039140 A1
反应条件
sodium methylate T=0 - 20°C; 19 h;
参考文献
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Zhuo; WANG, Tingjin; WU, Zuping; WEN, Qiuling
Patent: WO2014/22128 A1, 2014 ;
Location in patent: Paragraph 0149 ;
反应条件
T=0 - 20°C; 19.1667 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/157191 A2, 2008 ;
Location in patent: Page/Page column 78 ;
WO 2008/157191 A2
参考文献
US2014/134133 A1, ;
Page/Page column ;
反应条件
sulfuric acid; nitric acid T=90 - 100°C; 6 h;
参考文献
Linstroem, Stefan; Eriksson, Mikael; Grivas, Spiros
Acta Chemica Scandinavica, 1993 , vol. 47, # 8 p. 805 - 812
反应条件
1: trichlorophosphate / N,N-dimethyl-formamide / 3 h / Reflux 2: methanol / 0 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1569 - 1574
反应条件
1: SnCl2·2H2O; hydrogenchloride / 20 °C 2: pyridine View Scheme
参考文献
Calitor Sciences, LLC; Xi, Ning
Patent: US2014/134133 A1, 2014 ;
反应条件
1: SnCl2·2H2O / ethyl acetate / 4 h / Reflux 2: pyridine / 0 - 20 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; BOTYANSZKI, Janos; DICKERSON, Scott Howard; LEIVERS, Martin Robert; LI, Xiaofei; MCFADYEN, Robert Blount; REDMAN, Aniko Maria; SHOTWELL, John Bradford; XUE, Jianjun
Patent: WO2012/174312 A2, 2012 ;
WO 2012/174312 A2
反应条件
1: hydrogenchloride; iron / ethanol; water / 23 h / 10 - 25 °C / Industry scale; Inert atmosphere 2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere View Scheme
参考文献
GLAXOSMITHKLINE LLC; BOTYANSZKI, Janos; DICKERSON, Scott Howard; LEIVERS, Martin Robert; LI, Xiaofei; MCFADYEN, Robert Blount; REDMAN, Aniko Maria; SHOTWELL, John Bradford; XUE, Jianjun
Patent: WO2012/174312 A2, 2012 ;
WO 2012/174312 A2
