5-溴-2-甲氧基-3-硝基砒啶合成路线 （共 16 条）
反应条件
water; iron; ammonium chloride in ethanol T=95°C; 1 h;
参考文献
WO2008/33854 A1, ;
Page/Page column 74-75 ;
反应条件
1: SnCl2·2H2O / ethyl acetate / 4 h / Reflux 2: pyridine / 0 - 20 °C 3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; sodium carbonate / 1,4-dioxane / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1569 - 1574
反应条件
1: SnCl2·2H2O / acetic anhydride / 3 h / Reflux 2: pyridine / 20 h / 20 °C 3: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Reflux; Inert atmosphere 4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane; water / 2 h / 80 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; BOTYANSZKI, Janos; DICKERSON, Scott Howard; LEIVERS, Martin Robert; LI, Xiaofei; MCFADYEN, Robert Blount; REDMAN, Aniko Maria; SHOTWELL, John Bradford; XUE, Jianjun
Patent: WO2012/174312 A2, 2012 ;
WO 2012/174312 A2
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane 2 h; Reflux;
参考文献
WO2012/34526 A1, ;
Page/Page column 33 ;
WO 2012/034526 A1
反应条件
1: With tin(ll) chloride 3 h; Reflux; 2: With sodium hydroxide in dichloromethane; water; ethyl acetate T=20°C; 3 h;
参考文献
WO2010/139731 A1, ;
Page/Page column 169-170 ;
WO 2010/139731 A1
反应条件
1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / 2 h / Reflux
2: hydrogen / Raney-Ni / methanol / 2 h / 20 °C
3: pyridine / 20 °C
View Scheme
参考文献
Su, Weiguo; Zhang, Weihan; Yang, Haibin
Patent: US2013/190307 A1, 2013 ;
