1: 1) natrium amide / 1) benzene, reflux, 1,5 h, 2) reflux, 7 h. 2: 77 percent / potassium hydroxide / ethanol; H2O / 7 h / Heating 3: 350 mg / polyphosphoric acid / 24 h / 60 - 80 °C View Scheme

1: EtONa, HCl / 1)2 hrs. reflux, ethanol, toluen, 2)0 deg C, pH=2-3, water 2: 65 percent / H3PO4 / H2O / 8 h / Heating 3: 75 percent / hydroxylamine hydrochloride / ethanol / 3 h / Heating 4: Na / ethanol / 4 h / Heating View Scheme

1: EtONa, HCl / 1)2 hrs. reflux, ethanol, toluen, 2)0 deg C, pH=2-3, water 2: 65 percent / H3PO4 / H2O / 8 h / Heating 3: 75 percent / hydroxylamine hydrochloride / ethanol / 3 h / Heating 4: Na / ethanol / 4 h / Heating View Scheme

1: 1) natrium amide / 1) benzene, reflux, 1,5 h, 2) reflux, 7 h. 2: 77 percent / potassium hydroxide / ethanol; H2O / 7 h / Heating 3: 300 mg / polyphosphoric acid / 24 h / 60 - 80 °C View Scheme

potassium hydroxide

1: 69 percent / HCl / diethyl ether / 0 °C 2: 83 percent / ethanol / 7 h / Heating View Scheme

1: 1) natrium amide / 1) benzene, reflux, 1,5 h, 2) reflux, 7 h. 2: 1) natrium amide / 1) benzene, reflux, 7 h, 2) room temp. 36 h, 3) reflux, 7 h, 4) the metylation was repeated once again. 3: 75 percent / potassium hydroxide / ethane-1,2-diol / 15 h / Heating 4: 120 mg / polyphosphoric acid / 30 h / 100 °C View Scheme