3,5-二甲基-4-甲氧基苯甲腈合成路线 （共 5 条）
反应条件
in N,N-dimethyl-formamide T=136°C;
参考文献
ASTRAZENECA AB; BLID, Jan; GINMAN, Tobias; GRAVENFORS, Ylva; KARLSTROeM, Sofia; KOLMODIN, Karin; LINDSTROeM, Johan; PLOBECK, Niklas; RAHM, Fredrik; SWAHN, Britt-Marie; VIKLUND, Jenny; VON BERG, Stefan; VON KIESERITZKY, Fredrik
Patent: WO2011/2407 A1, 2011 ;
Location in patent: Page/Page column 74-75 ;
WO 2011/002407 A1
反应条件
in N,N-dimethyl-formamide T=180°C; Inert atmosphere;
参考文献
Zhang, Yu; Lu, Zhenjie; Desai, Aman; Wulff, William D.
Organic Letters, 2008 , vol. 10, # 23 p. 5429 - 5432
反应条件
potassium carbonate in acetone 18 h; Heating;
参考文献
Diana, Guy D.; Cutcliffe, David; Volkots, Deborah L.; Mallamo, John P.; Bailey, Thomas R.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3240 - 3250
反应条件
1: 62 percent / NaN3, NH4Cl / dimethylformamide / 24 h / 110 °C 2: 67 percent / K2CO3 / acetonitrile / 1 h / Heating 3: 96 percent / BBr3 / CH2Cl2 View Scheme
参考文献
Diana, Guy D.; Cutcliffe, David; Volkots, Deborah L.; Mallamo, John P.; Bailey, Thomas R.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3240 - 3250
反应条件
1: With sodium hydroxide in ethanol T=120°C; pressure reactor; 2: With hydrogenchloride in water
参考文献
Almirall, S.A.; Erra Sola, Montserrat; Aguilar Izquierdo, Nuria; Carrascal Riera, Marta; Taboada Martinez, Lorena; Navarro Romero, Eloisa; Vidal Juan, Bernat
Patent: EP2390252 A1, 2011 ;
Location in patent: Paragraph 0449; 0450 ;
EP 2390252 A1
