4-(三甲基甲硅烷基)苯甲酸合成路线 （共 16 条）
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, from -78 deg C to RT 2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, a) -78 deg C, 15 min, b) from -78 deg C to RT View Scheme
参考文献
Ekhato; Huang
Journal of Labelled Compounds and Radiopharmaceuticals, 1994 , vol. 34, # 3 p. 213 - 220
反应条件
potassium hydroxide 1.) benzene, 70 deg C, 45 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Fomin, V. A.; Ovchinnikova, Yu. I.
J. Gen. Chem. USSR (Engl. Transl.), 1987 , vol. 57, # 2 p. 452 - 456,393 - 397
反应条件
iodine cloride in tetrachloromethane 1.) RT, 30 min, 2.) reflux, 1 h;
参考文献
Ekhato; Huang
Journal of Labelled Compounds and Radiopharmaceuticals, 1994 , vol. 34, # 3 p. 213 - 220
参考文献
Benkeser, R. A.; Krysiak, H. R.
Journal of the American Chemical Society, 1953 , vol. 75, p. 4528 - 4531
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Gmelin Handbook: Si: MVol.C, 22, page 68 - 71
反应条件
1: 95 percent / iodine monochloride / CCl4 / 1.) RT, 30 min, 2.) reflux, 1 h 2: oxalyl chloride, DMF / toluene / 1 h / Ambient temperature View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 34, # 3 p. 213 - 220
反应条件
1: 95 percent / iodine monochloride / CCl4 / 1.) RT, 30 min, 2.) reflux, 1 h 2: oxalyl chloride, DMF / toluene / 1 h / Ambient temperature 3: LiCl, NaBH4 / 1,2-dimethoxy-ethane / 1 h View Scheme
参考文献
Ekhato; Huang
Journal of Labelled Compounds and Radiopharmaceuticals, 1994 , vol. 34, # 3 p. 213 - 220
