1-(6-氯-9H-嘌呤-9-基)-1-脱氧-N-甲基-2,3-O-异亚丙基-beta-D-呋喃核糖酰胺合成路线 （共 4 条）
反应条件
1: (3AS,4S,6R,6AR)-6-(6-chloro-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid With thionyl chloride in acetonitrile T=30°C; 4 h; 2: methylamine With N-ethyl-N,N-diisopropylamine in tetrahydrofuran; acetonitrile T=7°C; 13 h;
参考文献
CAN-FITE BIOPHARMA LTD.
Patent: WO2008/111082 A1, 2008 ;
Location in patent: Page/Page column 31-34 ;
反应条件
in chloroform T=10°C; 0.333333 h;
参考文献
Gallo-Rodriguez, Carola; Ji, Xiao-duo; Melman, Neli; Siegman, Barry D.; Sanders, Lawrence H.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 5 p. 636 - 646
反应条件
1: 60 percent / CrO3, glacial acetic acid / 48 h / Ambient temperature 2: SOCl2, N,N-dimethylformamide / CHCl3 / 6 h / Heating 3: CHCl3 / 0.33 h / 10 °C View Scheme
参考文献
Olsson; Kusachi; Thompson; Ukena; Padgett; Daly
Journal of medicinal chemistry, 1986 , vol. 29, # 9 p. 1683 - 1689
反应条件
1: Et3N / ethanol / 16 h / 75 °C 2: 1N HCl / 4 h / 60 °C View Scheme
参考文献
Gallo-Rodriguez, Carola; Ji, Xiao-duo; Melman, Neli; Siegman, Barry D.; Sanders, Lawrence H.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 5 p. 636 - 646
