2-(4-氟苯基)-噁唑-4-甲醛合成路线 （共 4 条）
反应条件
Dess-Martin periodane in dichloromethane T=0 - 20°C; 3 h;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby
Patent: WO2011/88187 A1, 2011 ;
Location in patent: Page/Page column 52 ;
反应条件
1.1: dibenzoyl peroxide / benzene / 0.25 h / Reflux 1.2: 2 h / Reflux 2.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3 h / -10 - 20 °C 3.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby
Patent: WO2011/88187 A1, 2011 ;
反应条件
1.1: dichloromethane / 24 h / 0 - 20 °C 2.1: dibenzoyl peroxide / benzene / 0.25 h / Reflux 2.2: 2 h / Reflux 3.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3 h / -10 - 20 °C 4.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby
Patent: WO2011/88187 A1, 2011 ;
反应条件
1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3 h / -10 - 20 °C 2: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby
Patent: WO2011/88187 A1, 2011 ;
