6-溴吡啶并[2,3-D]-2,4-二氨基嘧啶合成路线 （共 4 条）
反应条件
hydrogenchloride in ethanol 0.0833333 h; Heating; Yield given;
参考文献
Rosowsky, Andre; Chen, Han; Fu, Hongning; Queener, Sherry F.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 1 p. 59 - 67
反应条件
ammonium hydroxide in 1,4-dioxane 120 h; Ambient temperature;
参考文献
Taylor, Edward C.; Otiv, S. R.; Durucasu, Inci
Heterocycles, 1993 , vol. 36, # 8 p. 1883 - 1895
反应条件
1: 93 percent / p-chlorophenylphosphoro-dichloridate, pyridine / 24 h / Ambient temperature 2: 92 percent / Na / 0.25 h / Ambient temperature 3: 95 percent / aq. NH3 / dioxane / 12 h / Ambient temperature 4: 81 percent / aq. NH3 / dioxane / 120 h / Ambient temperature View Scheme
参考文献
Taylor, Edward C.; Otiv, S. R.; Durucasu, Inci
Heterocycles, 1993 , vol. 36, # 8 p. 1883 - 1895
反应条件
1: 92 percent / Na / 0.25 h / Ambient temperature 2: 95 percent / aq. NH3 / dioxane / 12 h / Ambient temperature 3: 81 percent / aq. NH3 / dioxane / 120 h / Ambient temperature View Scheme
参考文献
Taylor, Edward C.; Otiv, S. R.; Durucasu, Inci
Heterocycles, 1993 , vol. 36, # 8 p. 1883 - 1895
