benzoyl formate decarboxylase; thiamine diphosphate in water T=20°C; Condensation; pH=7.0; 20 h; Enzymatic reaction;

sulfuric acid in methanol T=20°C; 12 h;

1: water; lithium hydroxide hydrate / acetonitrile / 4 h / 50 - 60 °C 2: triethylamine / acetone / 0.08 h / 0 °C 3: sodium azide / acetone / 2 h / 20 °C 4: toluene / 2 h / Reflux; Inert atmosphere 5: water / 2 h / Reflux 6: sodium tetrahydroborate / methanol / 0.17 h / 0 - 20 °C / Inert atmosphere 7: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C 8: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 30 h / 20 °C View Scheme

1: triethylamine / acetone / 0.08 h / 0 °C 2: sodium azide / acetone / 2 h / 20 °C 3: toluene / 2 h / Reflux; Inert atmosphere 4: water / 2 h / Reflux 5: sodium tetrahydroborate / methanol / 0.17 h / 0 - 20 °C / Inert atmosphere 6: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C 7: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 30 h / 20 °C View Scheme

1: sodium tetrahydroborate / methanol / 0.17 h / 0 - 20 °C / Inert atmosphere 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C 3: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 30 h / 20 °C View Scheme

1: 1,4-diaza-bicyclo[2.2.2]octane / 30 °C / Sonication 2: 1H-imidazole; dimethyl sulfoxide / 20 °C / Inert atmosphere 3: water; lithium hydroxide hydrate / acetonitrile / 4 h / 50 - 60 °C 4: triethylamine / acetone / 0.08 h / 0 °C 5: sodium azide / acetone / 2 h / 20 °C 6: toluene / 2 h / Reflux; Inert atmosphere 7: water / 2 h / Reflux 8: sodium tetrahydroborate / methanol / 0.17 h / 0 - 20 °C / Inert atmosphere 9: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C 10: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 30 h / 20 °C View Scheme

1: 1H-imidazole; dimethyl sulfoxide / 20 °C / Inert atmosphere 2: water; lithium hydroxide hydrate / acetonitrile / 4 h / 50 - 60 °C 3: triethylamine / acetone / 0.08 h / 0 °C 4: sodium azide / acetone / 2 h / 20 °C 5: toluene / 2 h / Reflux; Inert atmosphere 6: water / 2 h / Reflux 7: sodium tetrahydroborate / methanol / 0.17 h / 0 - 20 °C / Inert atmosphere 8: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C 9: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 30 h / 20 °C View Scheme

1: (+/-)-1-(3-chlorophenyl)-2-hydroxypropan-1-one With 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride in dichloromethane T=-40°C; 0.5 h; 2: tert-butylamine in dichloromethane 12 h; Further stages.;

1: (+/-)-1-(3-chlorophenyl)-2-hydroxypropan-1-one With 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride in dichloromethane T=-40°C; 0.5 h; 2: tert-butylamine in dichloromethane 12 h; Further stages.;