1-(2-甲氧基苯基)-[1,4]二氮杂烷合成路线 （共 3 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) 0 deg C, 30 min; room temp., 1 h, 2.) reflux, overnight; Yield given;
参考文献
Hoeve, Wolter ten; Kruse, Chris, G.; Luteyn, Jan M.; Thiecke, Janet R. G.; Wynberg, Hans
Journal of Organic Chemistry, 1993 , vol. 58, # 19 p. 5101 - 5106
反应条件
1: 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; tris-(dibenzylideneacetone)dipalladium(0); triethylamine; potassium tert-butylate / toluene / 21 h / 110 °C 2: trifluoroacetic acid / water / 20 °C View Scheme
参考文献
Li, Aixiao; Mishra, Yogesh; Malik, Maninder; Wang, Qi; Li, Shihong; Taylor, Michelle; Reichert, David E.; Luedtke, Robert R.; MacH, Robert H.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 11 p. 2988 - 2998
反应条件
1: methanol / 48 h / 0 - 20 °C 2: 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; tris-(dibenzylideneacetone)dipalladium(0); triethylamine; potassium tert-butylate / toluene / 21 h / 110 °C 3: trifluoroacetic acid / water / 20 °C View Scheme
参考文献
Li, Aixiao; Mishra, Yogesh; Malik, Maninder; Wang, Qi; Li, Shihong; Taylor, Michelle; Reichert, David E.; Luedtke, Robert R.; MacH, Robert H.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 11 p. 2988 - 2998
