(R)-(+)-N-甲基-1-(1-萘基)乙基胺合成路线 （共 3 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; Inert atmosphereReflux; 2: With water; sodium hydroxide in tetrahydrofuran T=0°C;
参考文献
Ghosh, Arun K.; Takayama, Jun; Aubin, Yoann; Ratia, Kiira; Chaudhuri, Rima; Baez, Yahira; Sleeman, Katrina; Coughlin, Melissa; Nichols, Daniel B.; Mulhearn, Debbie C.; Prabhakar, Bellur S.; Baker, Susan C.; Johnson, Michael E.; Mesecar, Andrew D.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 16 p. 5228 - 5240
反应条件
1: (R)-N-(1-(naphthalen-1-yl)ethyl)formamide With lithium aluminium tetrahydride in tetrahydrofuran T=65°C; 3.5 h; Reflux; 2: sodium hydroxide in tetrahydrofuran; water T=0 - 5°C; 0.25 h;
参考文献
Krane Thvedt, Thor H.; Kaasa, Kristin; Sundby, Eirik; Charnock, Colin; Hoff, Bard Helge
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 482 - 496
反应条件
1: potassium carbonate, tetra-n-butylammonium iodide / CH2Cl2; H2O / 5 h 2: lithium aluminum hydride / tetrahydrofuran / Heating View Scheme
参考文献
Krane Thvedt, Thor H.; Kaasa, Kristin; Sundby, Eirik; Charnock, Colin; Hoff, Bard Helge
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 482 - 496
