去氢-ALPHA-拉杷醌合成路线 （共 26 条）
反应条件
1: With 2,3-dicyano-5,6-dichloro-p-benzoquinone in benzene
8 h; Reflux;
2: With sulfuric acid
1 h; Inert atmosphere;
参考文献
Eyong, Kenneth O.; Kumar, Ponminor S.; Kuete, Victor; Folefoc, Gabriel N.; Nkengfack, Ephriam A.; Baskaran, Sundarababu
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5387 - 5390
反应条件
sodium nitrite in water; acetic acid
T=80°C; 6 h; Further byproducts given;
参考文献
Singh; Jain; Krishna
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001 , vol. 40, # 2 p. 89 - 92
反应条件
1.1: YsOH
2.1: n-BuLi / tetrahydrofuran; hexane / 2 h / 20 °C
2.2: 93 percent / tetrahydrofuran / 20 °C
3.1: 85 percent / acetone; H2O / 12 h / Heating
4.1: 78 percent / AgO; HNO3 / tetrahydrofuran / 0.05 h
5.1: pyridine; SiO2 / CH2Cl2 / 24 h / 20 °C
View Scheme
参考文献
Tapia; Lizama; Lopez; Valderrama
Synthetic Communications, 2001 , vol. 31, # 4 p. 601 - 606
反应条件
acetic acid; sodium nitrite in water
T=80°C; 6 h;
参考文献
Singh, Pahup; Krishna, Vivek; Khandelwal, Poonam; Sharma, Kuldeep K.; Sharma
Journal of the Indian Chemical Society, 2010 , vol. 87, # 1 p. 85 - 95
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
T=25°C; 4 h;
参考文献
Singh, Pahup; Krishna, Vivek; Khandelwal, Poonam; Sharma, Kuldeep K.; Sharma
Journal of the Indian Chemical Society, 2010 , vol. 87, # 1 p. 85 - 95
反应条件
1: ethylenediamine diacetic acid / chloroform / 24 h / 20 °C / Inert atmosphere; Reflux
2: ammonium cerium (IV) nitrate / water; dimethyl sulfoxide / 12 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Wang, Xue; Chen, Ye; Lee, Yong Rok
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 1 p. 153 - 156
反应条件
1: ethylenediamine diacetic acid / chloroform / 24 h / 20 °C / Inert atmosphere; Reflux
2: ammonium cerium (IV) nitrate / water; dimethyl sulfoxide / 12 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Wang, Xue; Chen, Ye; Lee, Yong Rok
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 1 p. 153 - 156
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
0.666667 h; Heating;
参考文献
Gupta, R. B.; Khanna, R. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 1 p. 13 - 16
反应条件
N-bromosuccinmide
1) benzoyl peroxide, CCl4, reflux, 40 min 2) reflux, a few minutes; Yield given. Multistep reaction;
参考文献
Gupta, R. B.; Khanna, R. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 1 p. 13 - 16
反应条件
N-bromosuccinmide
1) benzoyl peroxide, CCl4, reflux, 40 min 2) reflux; Yield given. Multistep reaction;
参考文献
Gupta, R. B.; Khanna, R. N.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 1 p. 13 - 16
