6-氯-2-哌嗪-1,3-苯并噻唑合成路线 （共 2 条）
反应条件
potassium carbonate in acetonitrile 3 h; Heating / reflux;
参考文献
Breitenbucher, J. Guy; Cai, Hui; Edwards, James P.; Grice, Cheryl A.; Gu, Yin; Gustin, Darin J.; Karlsson, Lars; Khatuya, Haripada; Meduna, Steven P.; Pio, Barbara A.; Sun, Siquan; Tays, Kevin L.; Thumond, Robin L.; Wei, Jianmei
Patent: US2003/73672 A1, 2003 ;
反应条件
1: piperazine With copper(l) iodide 0.5 h; 2: With potassium hydroxide in water 1 h; 3: 2,6-dichloro-1,3-benzothiazole With benzyl-tri-(n-butyl)-ammonium bromide in chloroform; water T=20°C; 6 h; chemoselective reaction;
参考文献
Verma, Sanjeev K.; Acharya; Kaushik
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 5 p. 1324 - 1327
