2-氟-3-甲酰基-4-碘吡啶合成路线 （共 5 条）
反应条件
in tetrahydrofuran T=-78 - -50°C; 1 h;
参考文献
WO2009/18656 A1, ;
Page/Page column 91 ;
反应条件
lithium diisopropyl amide in tetrahydrofuran 1.) -75 deg C, 1 h, 2.) -75 deg C, 2 h;
参考文献
Rocca, P.; Cochennec, C.; Marsais, F.; Thomas-dit-Dumont, L.; Mallet, M.; et al.
Journal of Organic Chemistry, 1993 , vol. 58, # 27 p. 7832 - 7838
反应条件
1: With sodium tetrahydroborate in ethanol T=20°C; 1 h; 2: With hydrogenchloride in ethanol
参考文献
CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian K.; AUDIA, James Edmund; COTE, Alexandre; GEHLING, Victor S.; HARMANGE, Jean-christophe; HEWITT, Michael C.; LEBLANC, Yves; NAVESCHUK, Christopher G.; TAYLOR, Alexander M.; VASWANI, Rishi G.
Patent: WO2012/75383 A2, 2012 ;
Location in patent: Page/Page column 123 ;
反应条件
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene in water; tert-butyl alcohol T=20°C; 1.25 h;
参考文献
Amgen Inc.
Patent: WO2006/116713 A1, 2006 ;
Location in patent: Page/Page column 194-195 ;
WO 2006/116713 A1
反应条件
hydrazine in tetrahydrofuran
T=10 - 90°C; 2.08333 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2009/73300 A1, 2009 ;
Location in patent: Page/Page column 108 ;
WO 2009/073300 A1
