2-氯-4-碘-3-甲基吡啶合成路线 (共 3 条)
反应条件
lithium diisopropyl amide in tetrahydrofuran 1.) -75 deg C, 3 h, 2.) -75 deg C, 2 h;
参考文献
Journal of Organic Chemistry, , vol. 58, # 27 p. 7832 - 7838
反应条件
sodium hydrogencarbonate; palladium diacetate; 1,1'-bis(diphenylphosphino)ferrocene in N,N-dimethyl-formamide T=80°C;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1790650 A1, 2007 ;
Location in patent: Page/Page column 58-59 ;
反应条件
1: With N-ethyl-N,N-diisopropylamine; lithium chloride; tris-(dibenzylideneacetone)dipalladium(0) in N,N-dimethyl-formamide T=160°C; 0.333333 h; Microwave irradiation; 2: With sodium hydrogencarbonate in water; ethyl acetate; N,N-dimethyl-formamide
参考文献
NOVARTIS AG
Patent: WO2008/79933 A2, 2008 ;
Location in patent: Page/Page column 73-74 ;
WO 2008/079933 A2