2-氟-4-碘-5-甲基吡唑合成路线 （共 4 条）
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 2: With water in tetrahydrofuran T=-78 - 20°C;
参考文献
Wang, Le; Lin, Nan-Horng; Li, Qun; Henry, Rodger F.; Zhang, Haiying; Cohen, Jerome; Gu, Wen-Zhen; Marsh, Kennan C.; Bauch, Joy L.; Rosenberg, Saul H.; Sham, Hing L.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 18 p. 4603 - 4606
反应条件
1.1: LDA / tetrahydrofuran / -78 °C 1.2: 74 percent / I2 / tetrahydrofuran / -78 - 20 °C 2.1: LDA / tetrahydrofuran / -78 °C 2.2: 90 percent / H2O / tetrahydrofuran / -78 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 18 p. 4603 - 4606
反应条件
1: 2-Fluoro-4-iodo-5-methylpyridine With n-butyllithium; n-butyl-magnesium chloride in tetrahydrofuran; hexane; toluene 0.75 h; Cooling with ice; 2: carbon dioxide With hydrogenchloride in tetrahydrofuran; hexane; water; toluene
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/157273 A1, 2008 ;
Location in patent: Page/Page column 67 ;
反应条件
ammonium acetate in 1-methyl-pyrrolidin-2-one T=110°C; 144 h;
参考文献
IRM LLC; TULLY, David C.; RUCKER, Paul Vincent; ALPER, Phillip B.; MUTNICK, Daniel; CHIANELLI, Donatella
Patent: WO2012/87519 A1, 2012 ;
Location in patent: Page/Page column 122 ;
WO 2012/087519 A1
