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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
双氯芬酸
合成路线
（共 36 条）
15307-86-5
双氯芬酸
→
反应条件
69002-84-2
2-[(2,6-二氯苯基)氨基]-5-羟基苯乙酸
反应条件
sodium hydrogensulfite in water; acetonitrile Electrolysis;
参考文献
Stalder, Romain; Roth, Gregory P.
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 11 p. 1119 - 1123
70-18-8
还原型谷胱甘肽
+
15307-86-5
双氯芬酸
→
反应条件
反应条件
glucose-6-phosphate dehydrogenase; Glc 6P; cytochrome P450 3A4 co-expressed with human P450 oxidoreductase and cytochrome b5; human glutathione-S-transferase P1-1; NADPH in aq. phosphate buffer; dimethyl sulfoxide pH=7.4; 1 h; HeatingEnzymatic reaction;
参考文献
Boerma, Jan Simon; Vermeulen, Nico P.E.; Commandeur, Jan N.M.
Chemico-Biological Interactions, 2014 , vol. 207, # 1 p. 32 - 40
70-18-8
还原型谷胱甘肽
+
15307-86-5
双氯芬酸
→
反应条件
1526988-59-9
反应条件
glucose-6-phosphate dehydrogenase; Glc 6P; cytochrome P450 3A4 co-expressed with human P450 oxidoreductase and cytochrome b5; human glutathione-S-transferase P1-1; NADPH in aq. phosphate buffer; dimethyl sulfoxide T=37°C; pH=7.4; 1 h; Enzymatic reaction; Reagent/catalystTemperature;
参考文献
Boerma, Jan Simon; Vermeulen, Nico P.E.; Commandeur, Jan N.M.
Chemico-Biological Interactions, 2014 , vol. 207, # 1 p. 32 - 40
70-18-8
还原型谷胱甘肽
+
15307-86-5
双氯芬酸
→
反应条件
反应条件
glucose-6-phosphate dehydrogenase; Glc 6P; cytochrome P450 2C9 co-expressed with human P450 oxidoreductase and cytochrome b5; human glutathione-S-transferase P1-1; NADPH in aq. phosphate buffer; dimethyl sulfoxide pH=7.4; 1 h; HeatingEnzymatic reaction; Temperature;
参考文献
Boerma, Jan Simon; Vermeulen, Nico P.E.; Commandeur, Jan N.M.
Chemico-Biological Interactions, 2014 , vol. 207, # 1 p. 32 - 40
15307-86-5
双氯芬酸
→
反应条件
64118-84-9
4’-羟基双氯芬酸
反应条件
NADPH; recombinant human CYP2C9 in phosphate buffer T=37°C; pH=7.4; Enzyme kinetics; Further Variations:Catalysts;
参考文献
Perez, Sandra; Barcelo, Damia
Analytical Chemistry, 2008 , vol. 80, # 21 p. 8135 - 8145
70-18-8
还原型谷胱甘肽
+
15307-86-5
双氯芬酸
→
反应条件
1526988-59-9
反应条件
glucose-6-phosphate dehydrogenase; Glc 6P; cytochrome P450 2C9 co-expressed with human P450 oxidoreductase and cytochrome b5; human glutathione-S-transferase P1-1; NADPH in aq. phosphate buffer; dimethyl sulfoxide T=37°C; pH=7.4; 1 h; Enzymatic reaction; Reagent/catalystTemperature;
参考文献
Boerma, Jan Simon; Vermeulen, Nico P.E.; Commandeur, Jan N.M.
Chemico-Biological Interactions, 2014 , vol. 207, # 1 p. 32 - 40
67-56-1
甲醇
+
15307-86-5
双氯芬酸
→
反应条件
15307-78-5
{2-[(2,6-二氯苯基)氨基]苯基}乙酸甲酯
反应条件
1: With hydrogenchloride in water 6 h; Reflux; 2: With sodium carbonate in water
参考文献
EMS S.A.
Patent: US2012/115817 A1, 2012 ;
Location in patent: Page/Page column 46 ;
15307-86-5
双氯芬酸
+
18107-18-1
三甲基硅烷化重氮甲烷
→
反应条件
15307-78-5
{2-[(2,6-二氯苯基)氨基]苯基}乙酸甲酯
反应条件
in methanol; hexane; benzene T=25°C; 1 h;
参考文献
Oza, Vibha B.; Smith, Craig; Raman, Prakash; Koepf, Edward K.; Lashuel, Hilal A.; Petrassi, H. Mike; Chiang, Kyle P.; Powers, Evan T.; Sachettinni, James; Kelly, Jeffery W.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 321 - 332
15307-86-5
双氯芬酸
+
306776-38-5
→
反应条件
15362-40-0
1-(2,6-二氯苯基)-1,3-二氢-2H-吲哚-2-酮
反应条件
dicyclohexyl-carbodiimide in dichloromethane T=20°C; Acylation; 2 h;
参考文献
Bandarage; Chen; Fang; Garvey; Glavin; Janero; Letts; Mercer; Saha; Schroeder; Shumway; Tam
Journal of Medicinal Chemistry, 2000 , vol. 43, # 21 p. 4005 - 4016
15307-86-5
双氯芬酸
→
反应条件
15362-40-0
1-(2,6-二氯苯基)-1,3-二氢-2H-吲哚-2-酮
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C; 0.5 h;
参考文献
Chung, Man Chin; Dos Santos, Jean Leandro; Oliveira, Ednir Vizioli; Blau, Lorena; Renato Farina Menegon; Peccinini, Rosangela Goncalves
Molecules, 2009 , vol. 14, # 9 p. 3187 - 3197
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