2,6-二氯-N-苯基苯胺合成路线 （共 12 条）
反应条件
sodium hydroxide in chlorobenzene
参考文献
Osaka Yuki Kagaku Kogyo Kabushiki Kaisha
Patent: US4908479 A1, 1990 ;
反应条件
sodium hydroxide in water; N,N-dimethyl-formamide; toluene
参考文献
Yung Shin Pharm. Ind. Co., Ltd.
Patent: US5475139 A1, 1995 ;
反应条件
biphenyl-2-yl-di-tert-butyl-phosphane; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) in toluene 1 h; Heating;
参考文献
Buchwald, Stephen L.; Mauger, Christelle; Mignani, Gerard; Scholz, Ulrich
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 1-2 p. 23 - 39
反应条件
1: 99 percent / TiCl4 / toluene / 2 h / 20 °C 2: Et3N / dimethylformamide / 5 h / 95 - 100 °C View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 30, # 1 p. 38 - 40
反应条件
1: 99 percent / TiCl4 / toluene / 2 h / 20 °C 2: Et3N / dimethylformamide / 5 h / 95 - 100 °C View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 30, # 1 p. 38 - 40
反应条件
potassium phosphate; N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-dimethylamine; tris-(dibenzylideneacetone)dipalladium(0)
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 1-2 p. 23 - 39
反应条件
1: benzene / 2 h / Ambient temperature 2: AlCl3 / various solvent(s) / 20 h / Ambient temperature View Scheme
参考文献
Moser; Sallmann; Wiesenberg
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2358 - 2368
反应条件
T=106 - 110°C; Acetylation; 2 h;
参考文献
Ryabova; Bokanov; Isakovich; Kuzovkin; Grigor'ev; Levina; Shvedov; Granik
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 1 p. 38 - 40
反应条件
1: benzene / 6 h / Heating 2: 91 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / Ambient temperature 3: 84 percent / p-toluenesulfonic acid / benzene / 0.5 h / Heating 4: 97 percent / Zn / acetic acid / 4 h / Heating 5: 85 percent / 20percent NaOH / ethanol / 3 h / Heating View Scheme
参考文献
Moser; Sallmann; Wiesenberg
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2358 - 2368
反应条件
1: benzene / 6 h / Heating 2: 91 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / Ambient temperature 3: 84 percent / p-toluenesulfonic acid / benzene / 0.5 h / Heating 4: 91 percent / 2N NaOH / ethanol / 48 h / Heating 5: 85 percent / Raney nickel / ethanol / Heating View Scheme
参考文献
Tamura; Uenishi; Choi; et al.
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 5 p. 1995 - 1997
