1-甲基-5-三氟甲基-1H-吡唑合成路线 （共 11 条）
反应条件
T=100 - 130°C; Dehydration; 1.5 h;
参考文献
Bonacorso, Helio Gauze; Wastowski, Arci Dirceu; Zanatta, Nilo; Martins, Marcos Antonio Pinto
Synthetic Communications, 2000 , vol. 30, # 8 p. 1457 - 1465
反应条件
in methanol T=55°C; 20 h; Cooling with ice; Overall yield = 63 percent; Overall yield = 153 g;
参考文献
SOLVAY SA; BRAUN, Max Josef; FISCHER, Reiner
Patent: WO2013/167586 A1, 2013 ;
Location in patent: Page/Page column 10 ;
反应条件
1: in ethanol T=50°C; 0.25 h; 2: With hydrogenchloride in diethyl ether 1 h; Heating; Further stages.;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
in dichloromethane 2 h; Heating;
参考文献
Pavlik, James W.; Ayudhya, Theppawut Israsena Na; Tantayanon, Supawan
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1087 - 1089
反应条件
1: 1-methyl-5-(trifluoromethyl)pyrazole With lithium diisopropyl amide in tetrahydrofuran; hexane T=-75°C; 0.75 h; 2: carbon dioxide Further stages.;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
1: 67 percent / bromine; iron powder / 1 h / 100 °C 2: 70 percent / diisopropylamine; butyllithium / tetrahydrofuran; hexane / 0.08 h / -75 °C 3: 93 percent / zinc; NaOH / H2O / 1 h / 25 °C View Scheme
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
bromine; iron T=100°C; 1 h;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
1: 67 percent / bromine; iron powder / 1 h / 100 °C 2: 67 percent / tert-butyllithium / pentane; diethyl ether / 0.08 h / -75 °C View Scheme
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
1: 1-methyl-5-(trifluoromethyl)pyrazole With lithium diisopropyl amide in tetrahydrofuran; hexane T=-75°C; 0.75 h; 2: carbon dioxide Further stages.;
参考文献
European Journal of Organic Chemistry, , # 17 p. 2913 - 2920
反应条件
1: 67 percent / bromine; iron powder / 1 h / 100 °C 2: 88 percent / tert-butyllithium / pentane; diethyl ether / 0.08 h / -75 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 17 p. 2913 - 2920
