2-[2-(2-氨基乙氧基)乙氧基]乙基氨基甲酸叔丁酯 N-Boc-3,6-二氧杂-1,8-辛二胺合成路线 （共 22 条）
反应条件
1: 97 percent / tetrahydrofuran / 3 h / 20 °C 2: 97 percent / aq. NH4OH / methanol / 24 h / Heating View Scheme
参考文献
Phytochemistry, , vol. 63, # 3 p. 315 - 334
反应条件
1.1: triethylamine / dichloromethane / 0.83 h 2.1: triphenylphosphine / tetrahydrofuran / 5 h 2.2: 2 h View Scheme
参考文献
ChemBioChem, , vol. 11, # 12 p. 1769 - 1781
反应条件
1.1: hydrogenchloride; triphenylphosphine / water; toluene / 16 h / 0 - 20 °C 2.1: triethylamine / dichloromethane / 0.83 h 3.1: triphenylphosphine / tetrahydrofuran / 5 h 3.2: 2 h View Scheme
参考文献
ChemBioChem, , vol. 11, # 12 p. 1769 - 1781
反应条件
1.1: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 16 h / 80 °C 2.1: hydrogenchloride; triphenylphosphine / water; toluene / 16 h / 0 - 20 °C 3.1: triethylamine / dichloromethane / 0.83 h 4.1: triphenylphosphine / tetrahydrofuran / 5 h 4.2: 2 h View Scheme
参考文献
ChemBioChem, , vol. 11, # 12 p. 1769 - 1781
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 16 h / Inert atmosphere 2.1: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 16 h / 80 °C 3.1: hydrogenchloride; triphenylphosphine / water; toluene / 16 h / 0 - 20 °C 4.1: triethylamine / dichloromethane / 0.83 h 5.1: triphenylphosphine / tetrahydrofuran / 5 h 5.2: 2 h View Scheme
参考文献
ChemBioChem, , vol. 11, # 12 p. 1769 - 1781
反应条件
1: sodium azide / N,N-dimethyl-formamide / 8 h / 60 °C 2: palladium 10 on activated carbon; hydrogen / ethanol / 13 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 10 p. 3229 - 3241
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 1 h / 20 °C 2: sodium azide / N,N-dimethyl-formamide / 8 h / 60 °C 3: palladium 10 on activated carbon; hydrogen / ethanol / 13 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 10 p. 3229 - 3241
反应条件
1: 1.16 g / TfN3 / H2O; methanol; CH2Cl2 / 18 h / 20 °C 2: 56 percent / TFA / CH2Cl2 / 2.5 h View Scheme
参考文献
Lu, Yan; Gervay-Hague, Jacquelyn
Carbohydrate Research, 2007 , vol. 342, # 12-13 p. 1636 - 1650
反应条件
1: sodium hydrogencarbonate / water / 1.25 h / 0 - 20 °C / Saturated solution
2: dichloromethane / 0.17 h
View Scheme
参考文献
Willems, Lianne I.; Verdoes, Martijn; Florea, Bogdan I.; Van Der Marel, Gijsbert A.; Overkleeft, Herman S.
ChemBioChem, 2010 , vol. 11, # 12 p. 1769 - 1781
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 1 h
View Scheme
参考文献
Wang, Yanyan; El-Boubbou, Kheireddine; Kouyoumdjian, Hovig; Sun, Bin; Huang, Xuefei; Zeng, Xiangqun
Langmuir, 2010 , vol. 26, # 6 p. 4119 - 4125
