2-[2-(2-氨基乙氧基)乙氧基]乙基氨基甲酸叔丁酯 N-Boc-3,6-二氧杂-1,8-辛二胺合成路线 （共 22 条）
反应条件
1: With triethylamine in dichloromethane
2: With trifluoroacetic acid
T=20°C; 1 h;
参考文献
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY; SCHUSTER, Victor, L.; CHI, Yuling; WASMUTH, Andrew, S.; POTTORF, Richard, S.; OLSON, Gary, L.
Patent: WO2011/37610 A1, 2011 ;
Location in patent: Page/Page column 26 ;
WO 2011/037610 A1
反应条件
1: bis(trichloromethyl) carbonate; N-Boc-2,2'-(ethylene-1,2-dioxy)bisethylamine With N-ethyl-N,N-diisopropylamine in dichloromethane
T=15 - 20°C; 1 h;
2: carbonic acid bis-(4-formyl-2,6-dimethyl-phenyl) ester With 4-(N,N-dimethlyamino)pyridine in dichloromethane
T=20°C;
参考文献
Greenwald, Richard B.; Zhao, Hong; Xia, Jing; Martinez, Anthony
Journal of Medicinal Chemistry, 2003 , vol. 46, # 23 p. 5021 - 5030
